Coagulation potential of immobilised factor VIII in flow-dependent fibrin generation on platelet surfaces.

• Material Type: 博士論文
• ISSN: 0340-6245
• Title: Coagulation potential of immobilised factor VIII in flow-dependent fibrin generation on platelet surfaces.
• Volume: 110 2
• Author/Editor: Doi, Masaaki; Sugimoto, Mitsuhiko; Matsui, Hideto; Matsunari, Yasunori; Shima, Midori
• Author Heading: Doi, Masaaki; Sugimoto, Mitsuhiko; Matsui, Hideto; Matsunari, Yasunori; Shima, Midori
• Publication, Distribution, etc.: Schattauer
• Publication Date: 2013-08; 110 2
• Publication Date (W3CDTF): 2013-08
• Periodical title: Thrombosis and haemostasis
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2013-07-22
• Date Granted (W3CDTF): 2013-07-22
• Dissertation Number: 甲第602号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第602号
• Text Language Code: eng
• Subject Heading: Haemophilia; von Willebrand factor; factor VIII; flow; Fibrin generation
• Target Audience: 一般
• Note (General): type:Thesis; Coagulation factor VIII (FVIII) plays an essential role in haemostasis. To date, physiologic activity of FVIII circulating in the bloodstream (S-FVIII) is evaluated by classic coagulation assays. However, the functional relevance of FVIII (-von Willebrand factor complex) immobilised on thrombogenic surfaces (I-FVIII) remains unclear. We used an in vitro perfusion chamber system to evaluate the function of I-FVIII in the process of mural thrombus formation under whole blood flow conditions. In perfusion of either control or synthetic haemophilic blood, the intra-thrombus fibrin generation on platelet surfaces significantly increased as a function of I-FVIII, independent of S-FVIII, under high shear rate conditions. This I-FVIII effect was unvarying regardless of anti-FVIII inhibitor levels in synthetic haemophilic blood. Thus, our results illustrate coagulation potentials of immobilised clotting factors, distinct from those in the bloodstream, under physiologic flow conditions and may give a clue for novel therapeutic approaches for haemophilic patients with anti-FVIII inhibitors.; 博士（医学）・甲第602号・平成25年7月22日; The definitive version is available at " http://dx.doi.org/10.1160/TH13-02-0159 "; identifier:Thrombosis and haemostasis Vol.110 No.2 p.316-322; identifier:03406245; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2636; identifier:Thrombosis and haemostasis, 110(2): 316-322
• DOI: info:doi/10.1160/TH13-02-0159; https://doi.org/info:doi/10.1160/TH13-02-0159
• Persistent ID (NDL): info:ndljp/pid/8948391; https://dl.ndl.go.jp/pid/8948391
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2636
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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