並列タイトル等2型糖尿病患者におけるアミロイド沈着は膵島内にマクロファージの浸潤を伴いβ細胞の減少と関連する
2ガタ トウニョウビョウ カンジャ ニオケル アミロイド チンチャク ワ スイトウ ナイ ニ マクロファージ ノ シンジュン オ トモナイ βサイボウ ノ ゲンショウ ト カンレンスル
一般注記type:Thesis
Aims: Islet amyloid is a hallmark in type 2 diabetic subjects, but its implication in clinical features and development of islet pathology is still unclear.Methods: From 118 autopsy cases with type 2 diabetes, 26 cases with islet amyloid deposition (DA+) were selected. Twenty diabetic subjects without obvious amyloid deposition (DA ) matched for the age and diabetes duration and 20 non-diabetic subjects (ND) served for comparison. We examined the severity of amyloid deposition and its relationships with population of endocrine cells, expression of cell damage markers or macrophage infiltration. Correlation of clinical profile with islet pathology was also sought on the subset of the investigated patients.Results: b-Cell volume density was nearly 40% less in DA+ and 20% less in DA when compared to ND. Severity of amyloid deposition correlated with reduced volume densities of b-cell and a-cell, and increased body mass index (BMI), but not with duration of diabetes, age or HbA1c. Amyloid-rich islets contained an increased number of macrophages mixed with b-cells with oxidative stress-related DNA damage, characterized by gH2AX expression, and suppressed (pro)insulin mRNA expression.Conclusions: In Japanese type 2 diabetic patients, islet amyloid was more common with severe b-cell loss and high BMI, associated with macrophage infiltration.
identifier:Amyloid, 2014, 21(3), p.191-201
PubMed番号 : 25007035
DOIinfo:doi/10.3109/13506129.2014.937857
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