Islet amyloid with macrophage migration correlates with augmented b-cell deficits in type 2 diabetic patients

• Material Type: 博士論文
• ISSN: 1350-6129
• Title: Islet amyloid with macrophage migration correlates with augmented b-cell deficits in type 2 diabetic patients
• Volume: 21 3
• Author/Editor: Kamata, Kosuke; Mizukami, Hiroki; Inaba, Wataru; Tsuboi, Kentaro; Tateishi, Yoshinori; Yoshida, Taro; Yagihashi, Soroku
• Author Heading: Kamata, Kosuke; Mizukami, Hiroki; Inaba, Wataru; Tsuboi, Kentaro; Tateishi, Yoshinori; Yoshida, Taro; Yagihashi, Soroku
• Publication, Distribution, etc.: Informa healthcare
• Publication Date: 2014-09
• Publication Date (W3CDTF): 2014-09
• Alternative Title: 2型糖尿病患者におけるアミロイド沈着は膵島内にマクロファージの浸潤を伴いβ細胞の減少と関連する; 2ガタ トウニョウビョウ カンジャ ニオケル アミロイド チンチャク ワ スイトウ ナイ ニ マクロファージ ノ シンジュン オ トモナイ βサイボウ ノ ゲンショウ ト カンレンスル
• Periodical title: Amyloid
• Degree grantor/type: 弘前大学
• Date Granted: 2014-09-30
• Date Granted (W3CDTF): 2014-09-30
• Dissertation Number: 甲第1862号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第1862号
• Text Language Code: eng
• Subject Heading: b-cell loss; macrophage; morphometry; oxidative stress; pancreatic islet; type 2 diabetes; 医学
• NDC: 493.123
• Target Audience: 一般
• Note (General): type:Thesis; Aims: Islet amyloid is a hallmark in type 2 diabetic subjects, but its implication in clinical features and development of islet pathology is still unclear.Methods: From 118 autopsy cases with type 2 diabetes, 26 cases with islet amyloid deposition (DA+) were selected. Twenty diabetic subjects without obvious amyloid deposition (DA ) matched for the age and diabetes duration and 20 non-diabetic subjects (ND) served for comparison. We examined the severity of amyloid deposition and its relationships with population of endocrine cells, expression of cell damage markers or macrophage infiltration. Correlation of clinical profile with islet pathology was also sought on the subset of the investigated patients.Results: b-Cell volume density was nearly 40% less in DA+ and 20% less in DA when compared to ND. Severity of amyloid deposition correlated with reduced volume densities of b-cell and a-cell, and increased body mass index (BMI), but not with duration of diabetes, age or HbA1c. Amyloid-rich islets contained an increased number of macrophages mixed with b-cells with oxidative stress-related DNA damage, characterized by gH2AX expression, and suppressed (pro)insulin mRNA expression.Conclusions: In Japanese type 2 diabetic patients, islet amyloid was more common with severe b-cell loss and high BMI, associated with macrophage infiltration.; identifier:Amyloid, 2014, 21(3), p.191-201; PubMed番号 : 25007035
• DOI: info:doi/10.3109/13506129.2014.937857; https://doi.org/info:doi/10.3109/13506129.2014.937857
• Persistent ID (NDL): info:ndljp/pid/8953030; https://dl.ndl.go.jp/pid/8953030
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2018-03-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10129/5472
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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