Improvement in diagnostic performance of the revised total testosterone measuring system in Japanese women with polycystic ovary syndrome

• 資料種別: 博士論文
• ISSN: 1343-1420
• タイトル: Improvement in diagnostic performance of the revised total testosterone measuring system in Japanese women with polycystic ovary syndrome
• 巻次・部編番号: 61 1-2
• 著者・編者: Niki, Hirobumi; Matsuzaki, Toshiya; Kinouchi, Riyo; Iwasa, Takeshi; Kawami, Takako; Kato, Takeshi; Kuwahara, Akira; Irahara, Minoru
• 著者標目: Niki, Hirobumi; Matsuzaki, Toshiya; Kinouchi, Riyo; Iwasa, Takeshi; Kawami, Takako; Kato, Takeshi; Kuwahara, Akira; Irahara, Minoru
• 出版年月日等: 2014-02
• 出版年（W3CDTF）: 2014-02
• 並列タイトル等: テストステロン測定系の改良により日本女性における多嚢胞性卵巣症候群患者の診断効率は改善した; Diagnosis of PCOS by Revised T Assay
• タイトル（掲載誌）: The journal of medical investigation : JMI
• 授与機関名: 徳島大学
• 授与年月日: 2014-03-19
• 授与年月日（W3CDTF）: 2014-03-19
• 報告番号: 甲第2739号
• 学位: 博士（医学）
• 博論授与番号: 甲第2739号
• 本文の言語コード: eng
• 件名標目: PCOS; testosterone; diagnosis; LH; assay
• 対象利用者: 一般
• 一般注記: Hyperandrogenemia has become an important factor in the diagnosis of polycystic ovary syndrome (PCOS), in Japan as well as Western countries, since the Japanese PCOS diagnostic criteria were revised in 2007. The revised electrochemiluminescence immunoassay (ECLIA) reagent for total testosterone (T) (ECLusys TESTO II ; New T assay), which has lower cross-reactivity with DHEA-S than the previous reagent (ECLusys TESTO I ; Old T assay), has recently been developed. We studied the improvement between New and Old T assays in regards to the diagnostic performance of serum T for patients with PCOS. Serum T levels were measured in both normal women (Control, n=92) and PCOS patients (n=86). The rate of elevated T using each kit was significantly higher in the PCOS group than in the Control group, and significantly higher using New T assay (38/86, 44.2%) compared with Old T assay (26/86, 30.2%). A significant correlation was found between T level and body mass index, but not LH level. Furthermore, higher detection rates of hormonal abnormalities were seen in PCOS patients using combined measurement of both T and LH (63/80) compared with single measurement of either T (37/80) or LH (36/80). Therefore, the serum T assay is essential for the diagnosis of PCOS, and New T assay combined with the LH assay may improve the diagnostic process for PCOS.
• DOI: info:doi/10.2152/jmi.61.65; https://doi.org/info:doi/10.2152/jmi.61.65
• 国立国会図書館永続的識別子: info:ndljp/pid/9206780; https://dl.ndl.go.jp/pid/9206780
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2015-04-01T13:27:13+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/109522
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2019-09-09 再収集