Improvement in diagnostic performance of the revised total testosterone measuring system in Japanese women with polycystic ovary syndrome

• Material Type: 博士論文
• ISSN: 1343-1420
• Title: Improvement in diagnostic performance of the revised total testosterone measuring system in Japanese women with polycystic ovary syndrome
• Volume: 61 1-2
• Author/Editor: Niki, Hirobumi; Matsuzaki, Toshiya; Kinouchi, Riyo; Iwasa, Takeshi; Kawami, Takako; Kato, Takeshi; Kuwahara, Akira; Irahara, Minoru
• Author Heading: Niki, Hirobumi; Matsuzaki, Toshiya; Kinouchi, Riyo; Iwasa, Takeshi; Kawami, Takako; Kato, Takeshi; Kuwahara, Akira; Irahara, Minoru
• Publication Date: 2014-02
• Publication Date (W3CDTF): 2014-02
• Alternative Title: テストステロン測定系の改良により日本女性における多嚢胞性卵巣症候群患者の診断効率は改善した; Diagnosis of PCOS by Revised T Assay
• Periodical title: The journal of medical investigation : JMI
• Degree grantor/type: 徳島大学
• Date Granted: 2014-03-19
• Date Granted (W3CDTF): 2014-03-19
• Dissertation Number: 甲第2739号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第2739号
• Text Language Code: eng
• Subject Heading: PCOS; testosterone; diagnosis; LH; assay
• Target Audience: 一般
• Note (General): Hyperandrogenemia has become an important factor in the diagnosis of polycystic ovary syndrome (PCOS), in Japan as well as Western countries, since the Japanese PCOS diagnostic criteria were revised in 2007. The revised electrochemiluminescence immunoassay (ECLIA) reagent for total testosterone (T) (ECLusys TESTO II ; New T assay), which has lower cross-reactivity with DHEA-S than the previous reagent (ECLusys TESTO I ; Old T assay), has recently been developed. We studied the improvement between New and Old T assays in regards to the diagnostic performance of serum T for patients with PCOS. Serum T levels were measured in both normal women (Control, n=92) and PCOS patients (n=86). The rate of elevated T using each kit was significantly higher in the PCOS group than in the Control group, and significantly higher using New T assay (38/86, 44.2%) compared with Old T assay (26/86, 30.2%). A significant correlation was found between T level and body mass index, but not LH level. Furthermore, higher detection rates of hormonal abnormalities were seen in PCOS patients using combined measurement of both T and LH (63/80) compared with single measurement of either T (37/80) or LH (36/80). Therefore, the serum T assay is essential for the diagnosis of PCOS, and New T assay combined with the LH assay may improve the diagnostic process for PCOS.
• DOI: info:doi/10.2152/jmi.61.65; https://doi.org/info:doi/10.2152/jmi.61.65
• Persistent ID (NDL): info:ndljp/pid/9206780; https://dl.ndl.go.jp/pid/9206780
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-04-01T13:27:13+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/109522
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2019-09-09 再収集