Expression of REG Ⅲ and prognosis in head and neck cancer

• 資料種別: 博士論文
• ISSN: 1021-335X
• タイトル: Expression of REG Ⅲ and prognosis in head and neck cancer
• 巻次・部編番号: 30 2
• 著者・編者: Masui, Takashi; Ota, Ichiro; Itaya-Hironaka, Asako; Takeda, Maiko; Kasai, Takahiko; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Mikami, Shinji; Yane, Katsunari; Takasawa, Shin; Hosoi, Hiroshi
• 著者標目: Masui, Takashi; Ota, Ichiro; Itaya-Hironaka, Asako; Takeda, Maiko; Kasai, Takahiko; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Mikami, Shinji; Yane, Katsunari; Takasawa, Shin; Hosoi, Hiroshi
• 出版事項: National Hellenic Research Foundation / Spandidos
• 出版年月日等: 2013-08; 30 2
• 出版年（W3CDTF）: 2013-08
• 並列タイトル等: 頭頸部癌におけるREG Ⅲ の発現と予後
• タイトル（掲載誌）: Oncology reports
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2015-03-16
• 授与年月日（W3CDTF）: 2015-03-16
• 報告番号: 甲第625号
• 学位: 博士（医学）
• 博論授与番号: 甲第625号
• 本文の言語コード: eng
• 件名標目: REG Ⅲ; head and neck cancer; chemoradiosensitivity
• 対象利用者: 一般
• 一般注記: type:Thesis; Identification of a reliable biomarker for predicting prognosis in head and neck cancers is highly desirable and has long been sought. There have been several reports that members of the regenerating gene (REG) family are highly expressed in chronic inflammation and in tumors of the digestive organs. In addition, it has been described in several reports that REG expression is associated with the progression of digestive cancers. In the present study, we evaluated the effect of REG expression on the prognosis of hypopharyngeal cancer. We investigated 37 cases with hypopharyngeal squamous cell carcinoma, determined REG mRNA expression, which is easily detected in formalin-fixed paraffin-embedded tissues using the real-time reverse transcriptase-polymerase chain reaction method, and evaluated the survival rate using the Kaplan-Meier method. According to these results, REG Ⅲ mRNA expression was significantly associated with prolonged survival. Therefore, we constructed hypopharyngeal cancer cell lines transfected with REG Ⅲ and assessed the cell proliferation and chemosensitivity and/or radiosensitivity in vitro. Cells transfected with REG Ⅲ exhibited significantly lower cell proliferation and higher chemosensitivity and/or radiosensitivity compared with the control cells. These data suggest that REG Ⅲ may be a reliable biomarker of prognosis in hypopharyngeal cancer. This is the first report concerning the association of REG Ⅲ expression and the prognosis of head and neck squamous cell carcinoma including hypopharyngeal cancer.; 博士（医学）・甲第625号・平成27年3月16日; 本文のリンク：http://dx.doi.org/10.3892/or.2013.2521; Copyright © Spandidos Publications 2014; identifier:Oncology reports Vol.30 No.2 p.573-578; identifier:1021335X; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2937; identifier:Oncology reports, 30(2): 573-578
• DOI: info:doi/10.3892/or.2013.2521; https://doi.org/info:doi/10.3892/or.2013.2521
• 国立国会図書館永続的識別子: info:ndljp/pid/9277967; https://dl.ndl.go.jp/pid/9277967
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2015-05-01T13:23:17+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/2937
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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