Expression of REG Ⅲ and prognosis in head and neck cancer

• Material Type: 博士論文
• ISSN: 1021-335X
• Title: Expression of REG Ⅲ and prognosis in head and neck cancer
• Volume: 30 2
• Author/Editor: Masui, Takashi; Ota, Ichiro; Itaya-Hironaka, Asako; Takeda, Maiko; Kasai, Takahiko; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Mikami, Shinji; Yane, Katsunari; Takasawa, Shin; Hosoi, Hiroshi
• Author Heading: Masui, Takashi; Ota, Ichiro; Itaya-Hironaka, Asako; Takeda, Maiko; Kasai, Takahiko; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Mikami, Shinji; Yane, Katsunari; Takasawa, Shin; Hosoi, Hiroshi
• Publication, Distribution, etc.: National Hellenic Research Foundation / Spandidos
• Publication Date: 2013-08; 30 2
• Publication Date (W3CDTF): 2013-08
• Alternative Title: 頭頸部癌におけるREG Ⅲ の発現と予後
• Periodical title: Oncology reports
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2015-03-16
• Date Granted (W3CDTF): 2015-03-16
• Dissertation Number: 甲第625号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第625号
• Text Language Code: eng
• Subject Heading: REG Ⅲ; head and neck cancer; chemoradiosensitivity
• Target Audience: 一般
• Note (General): type:Thesis; Identification of a reliable biomarker for predicting prognosis in head and neck cancers is highly desirable and has long been sought. There have been several reports that members of the regenerating gene (REG) family are highly expressed in chronic inflammation and in tumors of the digestive organs. In addition, it has been described in several reports that REG expression is associated with the progression of digestive cancers. In the present study, we evaluated the effect of REG expression on the prognosis of hypopharyngeal cancer. We investigated 37 cases with hypopharyngeal squamous cell carcinoma, determined REG mRNA expression, which is easily detected in formalin-fixed paraffin-embedded tissues using the real-time reverse transcriptase-polymerase chain reaction method, and evaluated the survival rate using the Kaplan-Meier method. According to these results, REG Ⅲ mRNA expression was significantly associated with prolonged survival. Therefore, we constructed hypopharyngeal cancer cell lines transfected with REG Ⅲ and assessed the cell proliferation and chemosensitivity and/or radiosensitivity in vitro. Cells transfected with REG Ⅲ exhibited significantly lower cell proliferation and higher chemosensitivity and/or radiosensitivity compared with the control cells. These data suggest that REG Ⅲ may be a reliable biomarker of prognosis in hypopharyngeal cancer. This is the first report concerning the association of REG Ⅲ expression and the prognosis of head and neck squamous cell carcinoma including hypopharyngeal cancer.; 博士（医学）・甲第625号・平成27年3月16日; 本文のリンク：http://dx.doi.org/10.3892/or.2013.2521; Copyright © Spandidos Publications 2014; identifier:Oncology reports Vol.30 No.2 p.573-578; identifier:1021335X; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2937; identifier:Oncology reports, 30(2): 573-578
• DOI: info:doi/10.3892/or.2013.2521; https://doi.org/info:doi/10.3892/or.2013.2521
• Persistent ID (NDL): info:ndljp/pid/9277967; https://dl.ndl.go.jp/pid/9277967
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-05-01T13:23:17+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2937
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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