並列タイトル等放射性ヨウ素標識キナゾリン誘導体は非小細胞肺癌において放射線感受性を予測しうる
一般注記雑誌掲載タイトル：Relationship between uptake of a radioiodinated quinazoline derivative and radiosensitivity in non-small cell lung cancer雑誌名：American Journal of Nuclear Medicine and Molecular Imaging巻号：Volume 4, No.4 : p293-384, 2014
doctoral
医学系研究科
ObjectiveThe aim of this study was to determine whether the uptake of radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3′-iodophenoxy) quinazoline ([125I]PYK) can predict the response to radiotherapy of NSCLC cells in vitro.MethodsFour NSCLC cell lines PC9, HCC827, A549 and H1975 were used. The cells were irradiated with doses ranging from 2 Gy to 8 Gy and/or exposed to 1 μM gefitinib. The effects of radiation and gefitinib were assessed by CCK-8 assay. The uptake of [125I]PYK was determined by incubating cells with the tracer. Cell cycle and EGFR expression were assessed by flow cytometry.ResultsThe uptake of [125I]PYK in PC9 and HCC827 cells was higher than in A549 and H1975 cells. PC9 cells and HCC827 cells were more radiosensitive than A549 and H1975 cells. Gefitinib pretreatment reduced S phase fraction and enhanced radiation effect in PC9 and HCC827 cells.ConclusionThe uptake of [125I]PYK related to the effect of radiation in NSCLC cells. The results suggested that radioiodinated PYK might be useful in predicting the response of NSCLC in patients to radiotherapy.
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