A radioiodinated quinazolin derivative can predict radiosensitivity in non-small cell lung cancer

• Material Type: 博士論文
• Title: A radioiodinated quinazolin derivative can predict radiosensitivity in non-small cell lung cancer
• Author/Editor: Zhu, Huijun
• Author Heading: Zhu, Huijun
• Publication Date: 2013-09-20
• Publication Date (W3CDTF): 2013-09-20
• Alternative Title: 放射性ヨウ素標識キナゾリン誘導体は非小細胞肺癌において放射線感受性を予測しうる
• Degree grantor/type: 浜松医科大学
• Date Granted: 2013-09-20
• Date Granted (W3CDTF): 2013-09-20
• Dissertation Number: 甲第659号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 13802甲第659号
• Text Language Code: eng
• Subject Heading: [125I]PYK; irradiation; gefitinib; EGFR; NSCLC
• Target Audience: 一般
• Note (General): 雑誌掲載タイトル：Relationship between uptake of a radioiodinated quinazoline derivative and radiosensitivity in non-small cell lung cancer雑誌名：American Journal of Nuclear Medicine and Molecular Imaging巻号：Volume 4, No.4 : p293-384, 2014; doctoral; 医学系研究科; ObjectiveThe aim of this study was to determine whether the uptake of radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3′-iodophenoxy) quinazoline ([125I]PYK) can predict the response to radiotherapy of NSCLC cells in vitro.MethodsFour NSCLC cell lines PC9, HCC827, A549 and H1975 were used. The cells were irradiated with doses ranging from 2 Gy to 8 Gy and/or exposed to 1 μM gefitinib. The effects of radiation and gefitinib were assessed by CCK-8 assay. The uptake of [125I]PYK was determined by incubating cells with the tracer. Cell cycle and EGFR expression were assessed by flow cytometry.ResultsThe uptake of [125I]PYK in PC9 and HCC827 cells was higher than in A549 and H1975 cells. PC9 cells and HCC827 cells were more radiosensitive than A549 and H1975 cells. Gefitinib pretreatment reduced S phase fraction and enhanced radiation effect in PC9 and HCC827 cells.ConclusionThe uptake of [125I]PYK related to the effect of radiation in NSCLC cells. The results suggested that radioiodinated PYK might be useful in predicting the response of NSCLC in patients to radiotherapy.
• Persistent ID (NDL): info:ndljp/pid/9529537; https://dl.ndl.go.jp/pid/9529537
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-11-01T14:53:18+09:00
• Date Created (W3CDTF): 2018-08-27
• Format (IMT): application/pdf; text/html
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/2767; https://hama-med.repo.nii.ac.jp/records/2639
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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