Osteogenic Matrix Cell Sheets Facilitate Osteogenesis in Irradiated Rat Bone.

• 資料種別: 博士論文
• ISSN: 2314-6141
• タイトル: Osteogenic Matrix Cell Sheets Facilitate Osteogenesis in Irradiated Rat Bone.
• 巻次・部編番号: 2015
• 著者・編者: Uchihara, Yoshinobu; Akahane, Manabu; Shimizu, Takamasa; Ueha, Tomoyuki; Morita, Yusuke; Nakasaki, Shintaro; Kura, Tomohiko; Tohma, Yasuaki; Kido, Akira; Kawate, Kenji; Tanaka, Yasuhito
• 著者標目: Uchihara, Yoshinobu; Akahane, Manabu; Shimizu, Takamasa; Ueha, Tomoyuki; Morita, Yusuke; Nakasaki, Shintaro; Kura, Tomohiko; Tohma, Yasuaki; Kido, Akira; Kawate, Kenji; Tanaka, Yasuhito
• 出版事項: Hindawi Pub. Co.
• 出版年月日等: 2015
• 出版年（W3CDTF）: 2015
• 並列タイトル等: ラットにおいて骨形成細胞シートは放射線照射骨の骨形成能を促進させる
• タイトル（掲載誌）: BioMed research international
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2015-11-27
• 授与年月日（W3CDTF）: 2015-11-27
• 報告番号: 甲第642号
• 学位: 博士（医学）
• 博論授与番号: 甲第642号
• 本文の言語コード: eng
• 対象利用者: 一般
• 一般注記: type:Thesis; Reconstruction of large bone defects after resection of malignant musculoskeletal tumors is a significant challenge in orthopedic surgery. Extracorporeal autogenous irradiated bone grafting is a treatment option for bone reconstruction. However, nonunion often occurs because the osteogenic capacity is lost by irradiation. In the present study, we established an autogenous irradiated bone graft model in the rat femur to assess whether osteogenic matrix cell sheets improve osteogenesis of the irradiated bone. Osteogenic matrix cell sheets were prepared from bone marrow-derived stromal cells and co-transplanted with irradiated bone. X-ray images at 4 weeks after transplantation showed bridging callus formation around the irradiated bone. Micro-computed tomography images at 12 weeks postoperatively showed abundant callus formation in the whole circumference of the irradiated bone. Histology showed bone union between the irradiated bone and host femur. Mechanical testing showed that the failure force at the irradiated bone site was significantly higher than in the control group. Our study indicates that osteogenic matrix cell sheet transplantation might be a powerful method to facilitate osteogenesis in irradiated bones, which may become a treatment option for reconstruction of bone defects after resection of malignant musculoskeletal tumors.; 博士（医学）・甲第642号・平成25年11月27日; Copyright © 2015 Yoshinobu Uchihara et al. This is an open access article distributed under the Creative Commons Attribution License(https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; identifier:BioMed research international Vol.2015 Article ID.629168; identifier:23146141; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3103; identifier:BioMed research international, 2015: Article ID.629168
• DOI: info:doi/10.1155/2015/629168; https://doi.org/info:doi/10.1155/2015/629168
• 国立国会図書館永続的識別子: info:ndljp/pid/9577782; https://dl.ndl.go.jp/pid/9577782
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2016-01-05T14:58:43+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/3103
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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