Osteogenic Matrix Cell Sheets Facilitate Osteogenesis in Irradiated Rat Bone.

• Material Type: 博士論文
• ISSN: 2314-6141
• Title: Osteogenic Matrix Cell Sheets Facilitate Osteogenesis in Irradiated Rat Bone.
• Volume: 2015
• Author/Editor: Uchihara, Yoshinobu; Akahane, Manabu; Shimizu, Takamasa; Ueha, Tomoyuki; Morita, Yusuke; Nakasaki, Shintaro; Kura, Tomohiko; Tohma, Yasuaki; Kido, Akira; Kawate, Kenji; Tanaka, Yasuhito
• Author Heading: Uchihara, Yoshinobu; Akahane, Manabu; Shimizu, Takamasa; Ueha, Tomoyuki; Morita, Yusuke; Nakasaki, Shintaro; Kura, Tomohiko; Tohma, Yasuaki; Kido, Akira; Kawate, Kenji; Tanaka, Yasuhito
• Publication, Distribution, etc.: Hindawi Pub. Co.
• Publication Date: 2015
• Publication Date (W3CDTF): 2015
• Alternative Title: ラットにおいて骨形成細胞シートは放射線照射骨の骨形成能を促進させる
• Periodical title: BioMed research international
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2015-11-27
• Date Granted (W3CDTF): 2015-11-27
• Dissertation Number: 甲第642号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第642号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): type:Thesis; Reconstruction of large bone defects after resection of malignant musculoskeletal tumors is a significant challenge in orthopedic surgery. Extracorporeal autogenous irradiated bone grafting is a treatment option for bone reconstruction. However, nonunion often occurs because the osteogenic capacity is lost by irradiation. In the present study, we established an autogenous irradiated bone graft model in the rat femur to assess whether osteogenic matrix cell sheets improve osteogenesis of the irradiated bone. Osteogenic matrix cell sheets were prepared from bone marrow-derived stromal cells and co-transplanted with irradiated bone. X-ray images at 4 weeks after transplantation showed bridging callus formation around the irradiated bone. Micro-computed tomography images at 12 weeks postoperatively showed abundant callus formation in the whole circumference of the irradiated bone. Histology showed bone union between the irradiated bone and host femur. Mechanical testing showed that the failure force at the irradiated bone site was significantly higher than in the control group. Our study indicates that osteogenic matrix cell sheet transplantation might be a powerful method to facilitate osteogenesis in irradiated bones, which may become a treatment option for reconstruction of bone defects after resection of malignant musculoskeletal tumors.; 博士（医学）・甲第642号・平成25年11月27日; Copyright © 2015 Yoshinobu Uchihara et al. This is an open access article distributed under the Creative Commons Attribution License(https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; identifier:BioMed research international Vol.2015 Article ID.629168; identifier:23146141; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3103; identifier:BioMed research international, 2015: Article ID.629168
• DOI: info:doi/10.1155/2015/629168; https://doi.org/info:doi/10.1155/2015/629168
• Persistent ID (NDL): info:ndljp/pid/9577782; https://dl.ndl.go.jp/pid/9577782
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-01-05T14:58:43+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/3103
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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