Phototherapy with blue and green mixed-light is as effective against unconjugated jaundice as blue light and reduces oxidative stress in the Gunn rat model.

• 資料種別: 博士論文
• ISSN: 0378-3782
• タイトル: Phototherapy with blue and green mixed-light is as effective against unconjugated jaundice as blue light and reduces oxidative stress in the Gunn rat model.
• 巻次・部編番号: 91 7
• 著者・編者: Uchida, Yumiko; Morimoto, Yukihiro; Uchiike, Takao; Kamamoto, Tomoyuki :4/0000339; Hayashi, Tamaki; Arai, Ikuyo; Nishikubo, Toshiya; Takahashi, Yukihiro
• 著者標目: Uchida, Yumiko; Morimoto, Yukihiro; Uchiike, Takao; Kamamoto, Tomoyuki :4/0000339; Hayashi, Tamaki; Arai, Ikuyo; Nishikubo, Toshiya; Takahashi, Yukihiro
• 出版事項: Elsevier
• 出版年月日等: 2015-07; 91 7
• 出版年（W3CDTF）: 2015-07
• 並列タイトル等: 高非抱合型ビリルビン血症に対する光療法における青色と緑色光を混合した光療法は青色光単色と治療効果は同等であり、かつ光酸化ストレス反応を軽減する : Gunn ratモデルにおける検討
• タイトル（掲載誌）: Early human development Vol.No.p.(2015.07)
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2015-11-27
• 授与年月日（W3CDTF）: 2015-11-27
• 報告番号: 乙第1371号
• 学位: 博士（医学）
• 博論授与番号: 乙第1371号
• 本文の言語コード: eng
• 件名標目: Side effects; Hyperbilirubinemia; Neonate; Light emitting diode; Unbound bilirubin
• 対象利用者: 一般
• 一般注記: type:Thesis; OBJECTIVE:Phototherapy using blue light-emitting diodes (LED) is effective against neonatal jaundice. However, green light phototherapy also reduces unconjugated jaundice. We aimed to determine whether mixed blue and green light can relieve jaundice with minimal oxidative stress as effectively as either blue or green light alone in a rat model.METHODS:Gunn rats were exposed to phototherapy with blue (420-520 nm), filtered blue (FB; 440-520 nm without<440-nm wavelengths, FB50 (half the irradiance of filtered blue), mixed (filtered 50% blue and 50% green), and green (490-590 nm) LED irradiation for 24h. The effects of phototherapy are expressed as ratios of serum total (TB) and unbound (UB) bilirubin before and after exposure to each LED. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was measured by HPLC before and after exposure to each LED to determine photo-oxidative stress.RESULTS:Values < 1.00 indicate effective phototherapy. The ratios of TB and UB were decreased to 0.85, 0.89, 1.07, 0.90, and 1.04, and 0.85, 0.94, 0.93, 0.89, and 1.09 after exposure to blue, filtered blue, FB50, and filtered blue mixed with green LED, respectively. In contrast, urinary 8-OHdG increased to 2.03, 1.25, 0.96, 1.36, 1.31, and 1.23 after exposure to blue, filtered blue, FB50, mixed, green LED, and control, indicating side-effects (> 1.00), respectively.CONCLUSIONS:Blue plus green phototherapy is as effective as blue phototherapy and it attenuates irradiation-induced oxidative stress.PRACTICE IMPLICATIONS:Combined blue and green spectra might be effective against neonatal hyperbilirubinemia.; 博士（医学）・乙第1371号・平成27年11月27日; Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.; identifier:Early human development Vol.91 No.7 p.381–385 (2015.07); identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3109; identifier:Early human development Vol.No.p.(2015.07), 91(7): 381-385
• DOI: info:doi/10.1016/j.earlhumdev.2015.04.010; https://doi.org/info:doi/10.1016/j.earlhumdev.2015.04.010
• 国立国会図書館永続的識別子: info:ndljp/pid/9578183; https://dl.ndl.go.jp/pid/9578183
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2016-01-05T14:58:43+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/3109
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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