Phototherapy with blue and green mixed-light is as effective against unconjugated jaundice as blue light and reduces oxidative stress in the Gunn rat model. 7

• Material Type: 博士論文
• ISSN: 0378-3782
• Title: Phototherapy with blue and green mixed-light is as effective against unconjugated jaundice as blue light and reduces oxidative stress in the Gunn rat model.
• Volume: 91 7
• Author/Editor: Uchida, Yumiko; Morimoto, Yukihiro; Uchiike, Takao; Kamamoto, Tomoyuki :4/0000339; Hayashi, Tamaki; Arai, Ikuyo; Nishikubo, Toshiya; Takahashi, Yukihiro
• Author Heading: Uchida, Yumiko; Morimoto, Yukihiro; Uchiike, Takao; Kamamoto, Tomoyuki :4/0000339; Hayashi, Tamaki; Arai, Ikuyo; Nishikubo, Toshiya; Takahashi, Yukihiro
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2015-07; 91 7
• Publication Date (W3CDTF): 2015-07
• Alternative Title: 高非抱合型ビリルビン血症に対する光療法における青色と緑色光を混合した光療法は青色光単色と治療効果は同等であり、かつ光酸化ストレス反応を軽減する : Gunn ratモデルにおける検討
• Periodical title: Early human development Vol.No.p.(2015.07)
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2015-11-27
• Date Granted (W3CDTF): 2015-11-27
• Dissertation Number: 乙第1371号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第1371号
• Text Language Code: eng
• Subject Heading: Side effects; Hyperbilirubinemia; Neonate; Light emitting diode; Unbound bilirubin
• Target Audience: 一般
• Note (General): type:Thesis; OBJECTIVE:Phototherapy using blue light-emitting diodes (LED) is effective against neonatal jaundice. However, green light phototherapy also reduces unconjugated jaundice. We aimed to determine whether mixed blue and green light can relieve jaundice with minimal oxidative stress as effectively as either blue or green light alone in a rat model.METHODS:Gunn rats were exposed to phototherapy with blue (420-520 nm), filtered blue (FB; 440-520 nm without<440-nm wavelengths, FB50 (half the irradiance of filtered blue), mixed (filtered 50% blue and 50% green), and green (490-590 nm) LED irradiation for 24h. The effects of phototherapy are expressed as ratios of serum total (TB) and unbound (UB) bilirubin before and after exposure to each LED. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was measured by HPLC before and after exposure to each LED to determine photo-oxidative stress.RESULTS:Values < 1.00 indicate effective phototherapy. The ratios of TB and UB were decreased to 0.85, 0.89, 1.07, 0.90, and 1.04, and 0.85, 0.94, 0.93, 0.89, and 1.09 after exposure to blue, filtered blue, FB50, and filtered blue mixed with green LED, respectively. In contrast, urinary 8-OHdG increased to 2.03, 1.25, 0.96, 1.36, 1.31, and 1.23 after exposure to blue, filtered blue, FB50, mixed, green LED, and control, indicating side-effects (> 1.00), respectively.CONCLUSIONS:Blue plus green phototherapy is as effective as blue phototherapy and it attenuates irradiation-induced oxidative stress.PRACTICE IMPLICATIONS:Combined blue and green spectra might be effective against neonatal hyperbilirubinemia.; 博士（医学）・乙第1371号・平成27年11月27日; Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.; identifier:Early human development Vol.91 No.7 p.381–385 (2015.07); identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3109; identifier:Early human development Vol.No.p.(2015.07), 91(7): 381-385
• DOI: info:doi/10.1016/j.earlhumdev.2015.04.010; https://doi.org/info:doi/10.1016/j.earlhumdev.2015.04.010
• Persistent ID (NDL): info:ndljp/pid/9578183; https://dl.ndl.go.jp/pid/9578183
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-01-05T14:58:43+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/3109
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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