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Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes
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CiNii Research
Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes
- 資料種別
- 記事
- 著者
- Su-Ping Ngほか
- 出版者
- Portland Press Ltd.
- 出版年
- 2022-11-04
- 資料形態
- デジタル
- 掲載誌名
- Biochemical Journal 479 21
- 掲載ページ
- p.2279-2296
資料詳細
要約等：
- <jats:p>Certain metabolic intermediates produced during metabolism are known to regulate a wide range of cellular processes. Methylglyoxal (MG), a nat...
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デジタル
- 資料種別
- 記事
- 著者標目
- 出版年月日等
- 2022-11-04
- 出版年（W3CDTF）
- 2022-11-04
- タイトル（掲載誌）
- Biochemical Journal
- 巻号年月日等（掲載誌）
- 479 21
- 掲載巻
- 479
- 掲載号
- 21
- 掲載ページ
- 2279-2296
- 掲載年月日（W3CDTF）
- 2022-11-04
- ISSN（掲載誌）
- 02646021
- 出版事項（掲載誌）
- Portland Press Ltd.
- 対象利用者
- 一般
- DOI
- 10.1042/bcj20220271
- 作成日（W3CDTF）
- 2022-10-18
- 著作権情報
- http://creativecommons.org/licenses/by/2.0/
- 参照
- Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytesMethylglyoxal Activates the Target of Rapamycin Complex 2-Protein Kinase C Signaling Pathway in <i>Saccharomyces cerevisiae</i>PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humansThe c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical mannerMyosin motor Myo1c and its receptor NEMO/IKK-γ promote TNF-α–induced serine307 phosphorylation of IRS-1A new glycotoxins inhibitor attenuates insulin resistance in liver and fat cellsMethylglyoxal Forms Diverse Mercaptomethylimidazole Crosslinks with Thiol and Guanidine Pairs in Endogenous Metabolites and ProteinsAdverse Effects of Methylglyoxal on Transcriptome and Metabolic Changes in Visceral Adipose Tissue in a Prediabetic Rat ModelMetformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivoAdvanced glycation endproducts and its receptor for advanced glycation endproducts in obesityReduction of Glucose Uptake through Inhibition of Hexose Transporters and Enhancement of Their Endocytosis by Methylglyoxal in Saccharomyces cerevisiaeToxicity of dihydroxyacetone is exerted through the formation of methylglyoxal in <i>Saccharomyces cerevisiae</i>: effects on actin polarity and nuclear divisionAspirin Inhibits Serine Phosphorylation of Insulin Receptor Substrate 1 in Tumor Necrosis Factor-treated Cells through Targeting Multiple Serine KinasesDelayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet–Induced Obese MiceTAK1-TABs Complex: A Central Signalosome in Inflammatory ResponsesElevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 DiabetesThe role of advanced glycation end products in human infertilityIshige okamurae Ameliorates Methylglyoxal-Induced Nephrotoxicity via Reducing Oxidative Stress, RAGE Protein Expression, and Modulating MAPK, Nrf2/ARE Signaling Pathway in Mouse Glomerular Mesangial CellsDistinct roles of TRAF6 and TAK1 in the regulation of adipocyte survival, thermogenesis program, and high-fat diet-induced obesityThe attenuating effects of pyridoxamine on adipocyte hypertrophy and inflammation differ by adipocyte locationAlagebrium attenuates acute methylglyoxal‐induced glucose intolerance in Sprague‐Dawley ratsjun-N-terminal kinase regulates thrombin-induced PAI-1 gene expression in proximal tubular epithelial cellsRegulation of CREB Activation by P38 Mitogen Activated Protein Kinase during Human Primary Erythroblast DifferentiationEffect of Short-Term Hyperglycemia on Adipose Tissue Fluxes of Selected Cytokines In Vivo During Multiple Phases of Diet-Induced Weight Loss in Obese WomenJNK Signaling Promotes Intestinal Tumorigenesis Through Activation of mTOR Complex 1 in ApcΔ716 MiceOxidative Stress Activates the Plasminogen Activator Inhibitor Type 1 (PAI-1) Promoter through an AP-1 Response Element and Cooperates with Insulin for Additive Effects on PAI-1 TranscriptionMethylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivoGlyoxalase 1-knockdown in human aortic endothelial cells – effect on the proteome and endothelial function estimatesThe glyoxalase system in health and diseaseEffects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism – What We Know in Mammals and What We Can Learn From YeastRegulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2Turnover of the Active Fraction of IRS1 Involves Raptor-mTOR- and S6K1-Dependent Serine Phosphorylation in Cell Culture Models of Tuberous SclerosisAdapting to obesity with adipose tissue inflammationIn Vitro Phosphorylation of Insulin Receptor Substrate 1 by Protein Kinase C-ζ: Functional Analysis and Identification of Novel Phosphorylation SitesChronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley RatsThe protective effects of moscatilin against methylglyoxal-induced neurotoxicity via the regulation of p38/JNK MAPK pathways in PC12 neuron-like cellsInterplay and Effects of Temporal Changes in the Phosphorylation State of Serine-302, -307, and -318 of Insulin Receptor Substrate-1 on Insulin Action in Skeletal Muscle CellsMethylglyoxal Impairs Insulin Secretion of Pancreatic<i>β</i>-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKsDietary factors and low-grade inflammation in relation to overweight and obesityThe formation of methylglyoxal from triose phosphatesAntitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivoPhosphorylation of Raptor by p38β Participates in Arsenite-induced Mammalian Target of Rapamycin Complex 1 (mTORC1) ActivationMolecular mechanisms of methylglyoxal-induced aortic endothelial dysfunction in human vascular endothelial cellsInappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival DeficienciesApoptotic signaling in methylglyoxal‐treated human osteoblasts involves oxidative stress, c‐Jun N‐terminal kinase, caspase‐3, and p21‐activated kinase 2A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signallingDirect Cross-talk of Interleukin-6 and Insulin Signal Transduction via Insulin Receptor Substrate-1 in Skeletal Muscle CellsFROM MICE TO MEN: Insights into the Insulin Resistance SyndromesThe p38 and MK2 Kinase Cascade Phosphorylates Tuberin, the Tuberous Sclerosis 2 Gene Product, and Enhances Its Interaction with 14-3-3Osmotic Stress Regulates Mammalian Target of Rapamycin (mTOR) Complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor Protein PhosphorylationmTOR Signaling in Growth, Metabolism, and DiseaseThe Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and CausalityGlyoxalase System in Clinical Diabetes Mellitus and Correlation with Diabetic ComplicationsAdvanced glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytesGlyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetesMethylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related DiseasesA Role for p38 Stress-Activated Protein Kinase in Regulation of Cell Growth via TORC1Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1ROS Function in Redox Signaling and Oxidative StressDicarbonyl stress in cell and tissue dysfunction contributing to ageing and diseaseRegulation of Lipopolysaccharide-Induced Lung Inflammation by Plasminogen Activator Inhibitor-1 through a JNK-Mediated PathwayRegulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent MannerKnockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic MiceMAP kinases and mTOR mediate insulin-induced phosphorylation of Insulin Receptor Substrate-1 on serine residues 307, 612 and 632TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signallingInsulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathwaysTAK1 control of cell deathResveratrol Upregulates Nrf2 Expression To Attenuate Methylglyoxal-Induced Insulin Resistance in Hep G2 CellsGlyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in human endothelial cellsTumor Necrosis Factor α Produces Insulin Resistance in Skeletal Muscle by Activation of Inhibitor κB Kinase in a p38 MAPK-dependent MannerGlyoxalase system in yeasts: Structure, function, and physiologyIncreased Methylglyoxal and Oxidative Stress in Hypertensive Rat Vascular Smooth Muscle CellsMitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREBInterleukin-1β-Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 ExpressionIntermediary carbohydrate metabolism in embryonic lifeTNF‐α and adipocyte biologyA Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase KinaseIncreased plasma levels of the methylglyoxal in patients with newly diagnosed type 2 diabetes 初诊2型糖尿病患者血浆甲基乙二醛水平升高Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cellsAn Emerging Role of mTOR in Lipid BiosynthesisEnergy metabolism of white adipose tissue and insulin resistance in humansERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)Protein Kinase C-ζ-induced Phosphorylation of Ser318 in Insulin Receptor Substrate-1 (IRS-1) Attenuates the Interaction with the Insulin Receptor and the Tyrosine Phosphorylation of IRS-1Pro-inflammatory cytokines and adipose tissueRegulation of Insulin Receptor Substrate 1 Pleckstrin Homology Domain by Protein Kinase C: Role of Serine 24 PhosphorylationPositive and negative regulation of insulin signaling through IRS-1 phosphorylationMethylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cellsInhibition of the TNF-α^|^ndash;Induced Serine Phosphorylation of IRS-1 at 636/639 by AICAR
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
- Crossref科学研究費助成事業データベース科学研究費助成事業データベース科学研究費助成事業データベース科学研究費助成事業データベース