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Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes
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Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes
- Material type
- 記事
- Author
- Su-Ping Ngほか
- Publisher
- Portland Press Ltd.
- Publication date
- 2022-11-04
- Material Format
- Digital
- Journal name
- Biochemical Journal 479 21
- Publication Page
- p.2279-2296
Detailed bibliographic record
Summary, etc.：
- <jats:p>Certain metabolic intermediates produced during metabolism are known to regulate a wide range of cellular processes. Methylglyoxal (MG), a nat...
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Digital
- Material Type
- 記事
- Author Heading
- Publication Date
- 2022-11-04
- Publication Date (W3CDTF)
- 2022-11-04
- Periodical title
- Biochemical Journal
- No. or year of volume/issue
- 479 21
- Volume
- 479
- Issue
- 21
- Pages
- 2279-2296
- Publication date of volume/issue (W3CDTF)
- 2022-11-04
- ISSN (Periodical Title)
- 02646021
- Publication (Periodical Title)
- Portland Press Ltd.
- Subject Heading
- Target Audience
- 一般
- DOI
- 10.1042/bcj20220271
- Date Created (W3CDTF)
- 2022-10-18
- Rights (production)
- http://creativecommons.org/licenses/by/2.0/
- Related Material (URI)
- References
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cyclopentyl diester in vitro and in vivoPhosphorylation of Raptor by p38β Participates in Arsenite-induced Mammalian Target of Rapamycin Complex 1 (mTORC1) ActivationMolecular mechanisms of methylglyoxal-induced aortic endothelial dysfunction in human vascular endothelial cellsInappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival DeficienciesApoptotic signaling in methylglyoxal‐treated human osteoblasts involves oxidative stress, c‐Jun N‐terminal kinase, caspase‐3, and p21‐activated kinase 2A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signallingDirect Cross-talk of Interleukin-6 and Insulin Signal Transduction via Insulin Receptor Substrate-1 in Skeletal Muscle CellsFROM MICE TO MEN: Insights into the Insulin Resistance SyndromesThe p38 and MK2 Kinase Cascade Phosphorylates Tuberin, the Tuberous Sclerosis 2 Gene Product, and Enhances Its Interaction with 14-3-3Osmotic Stress Regulates Mammalian Target of Rapamycin (mTOR) Complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor Protein PhosphorylationmTOR Signaling in Growth, Metabolism, and DiseaseThe Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and CausalityGlyoxalase System in Clinical Diabetes Mellitus and Correlation with Diabetic ComplicationsAdvanced glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytesGlyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetesMethylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related DiseasesA Role for p38 Stress-Activated Protein Kinase in Regulation of Cell Growth via TORC1Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE 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