生体肝移植から15年後に発症した急速進行性の悪性リンパ腫の一剖検例
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- Material Type
- 記事
- Author/Editor
- 佐野 有哉有永 照子真田 咲子天野 恵介堤 翼中野 暖山口 真紀長藤 宏司三好 寛明秋葉 純川口 巧
- Alternative Title
- An Autopsy Case of Rapidly Progressive Malignant Lymphoma 15 Years After Living Donor Liver Transplantation
- Periodical title
- 肝臓
- No. or year of volume/issue
- 66(12):2025.12
- Volume
- 66
- Issue
- 12
- Pages
- 533-541
- Publication date of volume/issue (W3CDTF)
- 2025-12
- ISSN (Periodical Title)
- 0451-4203
- ISSN-L (Periodical Title)
- 0451-4203
- Publication (Periodical Title)
- 東京 : 日本肝臓学会
- Place of Publication (Country Code)
- JP
- Text Language Code
- jpn
- Subject Heading
- NDLC
- Target Audience
- 一般
- Holding library
- 国立国会図書館
- Call No.
- Z19-130
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- Bibliographic ID (NDL)
- 034458564
- Bibliographic Record Category (NDL)
- 632
- Summary, etc.
- <p>The patient was a woman in her 70s. She died approximately 1 month after the onset of symptoms due to malignant lymphoma, which developed 15 years after undergoing liver transplantation. It was difficult to obtain tissue samples and establish a definitive diagnosis before her death; a diagnosis of diffuse large B-cell lymphoma was made during the pathological autopsy. EBV-DNA and soluble interleukin-2 receptor levels, which were elevated at the onset of the disease, were measured from stored serum samples collected up to 1 year prior to disease onset to assess their usefulness for early diagnosis. However, no significant elevation was observed before the onset of symptoms in either marker. The incidence of de novo malignancies after liver transplantation is considered high and may be associated with immunosuppressive therapy, although the exact mechanisms remain unclear. It is desirable to establish protocols for the adjustment of immunosuppressive drugs and for the screening of de novo malignancies.</p><p>症例は70歳代女性．肝移植後15年目に発症した悪性リンパ腫のために症状出現から約1カ月の経過で死亡退院となった．生前には観血的な組織採取は困難で確定診断には至らなかったが，病理解剖によりびまん性大細胞型B細胞性リンパ腫と診断された．発症時に上昇を認めたEBV-DNAと可溶性IL2レセプターについて，発症前1年間の保存血清を用いて早期診断への有用性を検討したが，いずれも発症前には有意な上昇は認めなかった．肝移植後のde novo悪性腫瘍は高率とされ，肝移植患者にとって重大な合併症の1つであり，原因として免疫抑制薬などの関連が示唆されるが詳細は不明である．de novo悪性腫瘍に対する取り組みとして免疫抑制薬の調整や癌スクリーニングのプロトコールの確立が望まれる．</p>
- DOI
- 10.2957/kanzo.66.533
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE
- Summary, etc.
- <p>症例は70歳代女性．肝移植後15年目に発症した悪性リンパ腫のために症状出現から約1カ月の経過で死亡退院となった．生前には観血的な組織採取は困難で確定診断には至らなかったが，病理解剖によりびまん性大細胞型B細胞性リンパ腫と診断された．発症時に上昇を認めたEBV-DNAと可溶性IL2レセプターについて，発症前1年間の保存血清を用いて早期診断への有用性を検討したが，いずれも発症前には有意な上昇は認めなかった．肝移植後のde novo悪性腫瘍は高率とされ，肝移植患者にとって重大な合併症の1つであり，原因として免疫抑制薬などの関連が示唆されるが詳細は不明である．de novo悪性腫瘍に対する取り組みとして免疫抑制薬の調整や癌スクリーニングのプロトコールの確立が望まれる．</p>
- DOI
- 10.2957/kanzo.66.533
- Related Material (URI)
- References
- De Novo Malignancies Following Liver Transplantation: Results From a Multicentric Study in Central and Southern Italy, 1990–2008Evolution and management of de novo neoplasm post-liver transplantation: a 20-year experience from a single European centreThe Role of mTOR Inhibitors in the Management of Posttransplant MalignancyLong-term Probability of and Mortality From De Novo Malignancy After Liver TransplantationPOST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERClinical Characteristics and Survival Analysis of Patients With Second Primary Malignancies After Hepatocellular Carcinoma Liver TransplantationTransjugular liver biopsy – Indications, adequacy, quality of specimens, and complications – A systematic reviewSpectrum of Cancer Risk Among US Solid Organ Transplant RecipientsReview of Epstein–Barr virus and post‐transplant lymphoproliferative disorder post‐solid organ transplantation (Review Article)De Novo Malignancies After Adult-to-Adult Living-Donor Liver Transplantation With a Malignancy Surveillance ProgramEpstein–Barr virus (EBV) DNA in whole blood as a superior prognostic and monitoring factor than EBV-encoded small RNA in situ hybridization in diffuse large B-cell lymphomaClinical Usefulness of Transjugular Liver Biopsy in Patients With Hematological Diseases With Liver DysfunctionRecent insights in the pathogenesis of post-transplantation lymphoproliferative disordersDe Novo Internal Neoplasms after Liver Transplantation: Increased Risk and Aggressive Behavior in Recent Years?18F-FDG PET/CT in the management of patients with post-transplant lymphoproliferative disorderHepatic pseudolymphoma: imaging–pathologic correlation with special reference to hemodynamic analysisPrognostic significance of Epstein–Barr virus DNA detection in pretreatment serum in diffuse large B‐cell lymphomaThe Changing Epidemiology of Posttransplant Lymphoproliferative Disorder in Adult Solid Organ Transplant Recipients Over 30 Years
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link Center雑誌記事索引データベースCrossref
- Bibliographic ID (NDL)
- 034458564