くも膜下出血後の脳血管攣縮予防におけるクラゾセンタンの初期治療経験

• Material Type: 記事
• Title: くも膜下出血後の脳血管攣縮予防におけるクラゾセンタンの初期治療経験
• Author Heading: 渡邊 亨; 荒木 芳生; 宇田 憲司; 家永 惇平; 加藤 信靖; 礒澤 佑一郎; 酒井 洋輔; 塚田 哲也; 石川 隆之; 坂本 悠介; 村岡 真輔; 永谷 哲也; 関 行雄; 齋藤 竜太
• Publication Date: 2024
• Publication Date (W3CDTF): 2024
• Periodical title: 脳卒中の外科
• No. or year of volume/issue: 52 4
• Volume: 52
• Issue: 4
• Pages: 258-264
• Publication date of volume/issue (W3CDTF): 2024
• ISSN (Periodical Title): 09145508
• Publication (Periodical Title): The Japanese Society on Surgery for Cerebral Stroke
• Text Language Code: ja
• Subject Heading: clazosentan; delayed cerebral ischemia; fluid retention
• Target Audience: 一般
• DOI: 10.2335/scs.52.258; https://doi.org/10.2335/scs.52.258
• Related Material (URI): https://www.jstage.jst.go.jp/article/scs/52/4/52_258/_pdf; https://search.jamas.or.jp/link/ui/2024300590
• References: 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association; https://cir.nii.ac.jp/crid/1360018295359309056; Effects of clazosentan on cerebral vasospasm–related morbidity and all-cause mortality after aneurysmal subarachnoid hemorrhage: two randomized phase 3 trials in Japanese patients; https://cir.nii.ac.jp/crid/1360298345010117120; New insights into the causes and therapy of cerebral vasospasm following subarachnoid hemorrhage; https://cir.nii.ac.jp/crid/1360583650977351808; Preventive Effect of Clazosentan against Cerebral Vasospasm after Clipping Surgery for Aneurysmal Subarachnoid Hemorrhage in Japanese and Korean Patients; https://cir.nii.ac.jp/crid/1360855568760718336; Real-world data of clazosentan in combination therapy for aneurysmal subarachnoid hemorrhage: a multicenter retrospective cohort study; https://cir.nii.ac.jp/crid/1360865123387787904; Definition of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage as an Outcome Event in Clinical Trials and Observational Studies; https://cir.nii.ac.jp/crid/1361418518870467456; Prevention of delayed vasospasm by an endothelin ETA receptor antagonist, BQ-123: change of ETA receptor mRNA expression in a canine subarachnoid hemorrhage model; https://cir.nii.ac.jp/crid/1361699994881324160; The International Cooperative Study on the Timing of Aneurysm Surgery; https://cir.nii.ac.jp/crid/1361981469694953344; Endothelin concentrations in patients with aneurysmal subarachnoid hemorrhage; https://cir.nii.ac.jp/crid/1362825896302731904; Comparison between clipping and coiling on the incidence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis; https://cir.nii.ac.jp/crid/1363107369385713920; Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2); https://cir.nii.ac.jp/crid/1363388846009574144; Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1); https://cir.nii.ac.jp/crid/1363388846123153920
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• Original Data Provider (Database): Japan Link Center; https://japanlinkcenter.org/top; Crossref; https://www.crossref.org

• Summary, etc.: <p>クラゾセンタンはくも膜下出血後のスパズムに伴う遅発性脳虚血（delayed cerebral ischemia：DCI）および新規脳梗塞の発症を抑制するために使用される新規薬剤である．この研究ではクラゾセンタンを使用した当科での約 1 年間の初期治療経験について調査した．評価項目は患者背景，臨...