Abnormal pontine activation in pathological laughing as shown by functional magnetic resonance imaging

Material type: 文書・図像類

Author: KOSAKA, Hほか

Publisher: BMJ Publishing Group

Publication date: 2006-12

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Note (General)：: To explore the aetiology of pathological laughing, a 65-year-old woman with pathological laughing was examined by 3-T functional magnetic resonance im...

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Material Type: 文書・図像類
Title: Abnormal pontine activation in pathological laughing as shown by functional magnetic resonance imaging
Author/Editor: KOSAKA, H
OMATA, N
OMORI, M
SHIMOYAMA, T
MURATA, T
KASHIKURA, K
TAKAHASHI, T
MURAYAMA, J
YONEKURA, Y
WADA, Y
Author Heading: KOSAKA, H
OMATA, N
OMORI, M
SHIMOYAMA, T
MURATA, T
KASHIKURA, K
TAKAHASHI, T
MURAYAMA, J
YONEKURA, Y
WADA, Y
Publication, Distribution, etc.: BMJ Publishing Group
Publication Date: 2006-12
Publication Date (W3CDTF): 2006-12
Periodical title: Journal of neurology, neurosurgery and psychiatry
No. or year of volume/issue: 77 12
Volume: 77
Issue: 12
Pages: 1376-1380
Text Language Code: eng
Target Audience: 一般
Note (General): To explore the aetiology of pathological laughing, a 65-year-old woman with pathological laughing was examined by 3-T functional magnetic resonance imaging (fMRI) before and after treatment with drugs. Here, we report that the patient consistently showed exaggerated pontine activation during the performance of three tasks before treatment, whereas abnormal pontine activation was no longer found after successful treatment with the selective serotonin reuptake inhibitor, paroxetine. Our findings in this first fMRI study of pathological laughing suggest that serotonergic replacement decreases the aberrant activity in a circuit that involves the pons.
Access Restrictions: 限定公開
Related Material (DOI): 10.1136/jnnp.2005.073288
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ