Temperature-sensitive defects of the GSP1gene, yeast Ran homologue, activate the Tel1-dependent pathway

Material type: 文書・図像類

Author: HAYASHI, Naoyukiほか

Publisher: Elsevier Science B.V.

Publication date: 2007-02

Material Format: Digital

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Note (General)：: RanGTPase is involved in many cellular processes. It functions in nuclear-cytosolic transport and centrosome formation. Ran also localizes to chromati...

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Material Type: 文書・図像類
Title: Temperature-sensitive defects of the GSP1gene, yeast Ran homologue, activate the Tel1-dependent pathway
Author/Editor: HAYASHI, Naoyuki
MURAKAMI, Seishi
TSURUSAKI, Susumu
NAGAURA, Zen-ichiro
OKI, Masaya
NISHITANI, Hideo
KOBAYASHI, Masahiko
SHIMIZU, Hiroko
YAMAMOTO, Kenichi
NISHIMOTO, Takeharu
Author Heading: HAYASHI, Naoyuki
MURAKAMI, Seishi
TSURUSAKI, Susumu
NAGAURA, Zen-ichiro
OKI, Masaya
NISHITANI, Hideo
KOBAYASHI, Masahiko
SHIMIZU, Hiroko
YAMAMOTO, Kenichi
NISHIMOTO, Takeharu
Publication, Distribution, etc.: Elsevier Science B.V.
Publication Date: 2007-02
Publication Date (W3CDTF): 2007-02
Periodical title: Biochemical and Biophysical Research Communications
No. or year of volume/issue: 353 2
Volume: 353
Issue: 2
Pages: 330-336
ISSN (Periodical Title): ISSN : 0006-291X
Text Language Code: eng
Subject Heading: Ran
Gsp1
checkpoint
ATM kinase
Mec1
Tel1
Rad53
yeast
replication
signal transduction
Target Audience: 一般
Note (General): RanGTPase is involved in many cellular processes. It functions in nuclear-cytosolic transport and centrosome formation. Ran also localizes to chromatin as RCC1 does, its guanine nucleotide exchange factor, but Ran's function on chromatin is not known. We found that gsp1, a temperature-sensitive mutant of GSP1, a Saccharomyces cerevisiae Ran homologue, suppressed the hydroxyurea (HU) and ultra violet (UV) sensitivities of the mec1 mutant. In UV-irradiated mec1 gsp1 cells, Rad53 was phosphorylated despite the lack of Mec1. This suppression depended on the TEL1 gene, given that the triple mutant, mec1 gsp1 tel1, was unable to grow. The gsp1 mutations also suppressed the HU sensitivity of the rad9 mutant in a Tel1-dependent manner, but not the HU sensitivity of the rad53 mutant. These results indicated that Rad53 was activated by the Tel1 pathway in mec1 gsp1 cells, suggesting that Gsp1 helps regulate the role switching the ATM family kinases Mec1 and Tel1.
Access Restrictions: 限定公開
Related Material (DOI): 10.1016/j.bbrc.2006.12.028
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ