Low-intensity pulsed ultrasound enhances bone formation around miniscrew implants

• Material Type: 博士論文
• Title: Low-intensity pulsed ultrasound enhances bone formation around miniscrew implants
• Author/Editor: Ganzorig, Khaliunaa; Kuroda, Shingo; Maeda, Yuichi; Mansjur, Karima; Sato, Minami; Nagata, Kumiko; Tanaka, Eiji
• Author Heading: Ganzorig, Khaliunaa; Kuroda, Shingo; Maeda, Yuichi; Mansjur, Karima; Sato, Minami; Nagata, Kumiko; Tanaka, Eiji
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2015-03-04
• Publication Date (W3CDTF): 2015-03-04
• Alternative Title: LIPUSはミニスクリューインプラント周囲の骨形成を促進する
• Periodical title: Archives of Oral Biology
• No. or year of volume/issue: 60 6
• Volume: 60
• Issue: 6
• Pages: 902-910
• ISSN (Periodical Title): ISSN : 0003-9969
• Degree grantor/type: 徳島大学
• Date Granted: 2015-09-16
• Dissertation Number: 甲第2863号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Low-intensity pulsed ultrasound; miniscrew implant; bone formation; stainless steel and titanium
• Target Audience: 一般
• Note (General): Miniscrew implants (MSIs) are currently used to provide absolute anchorage in orthodontics; however, their initial stability is an issue of concern. Application of low-intensity pulsed ultrasound (LIPUS) can promote bone healing. Therefore, LIPUS application may stimulate bone formation around MSIs and enhance their initial stability. Aim. To investigate the effect of LIPUS exposure on bone formation after implantation of titanium (Ti) and stainless steel (SS) MSIs. Methods. MSIs made of Ti-6Al-4V and 316L SS were placed on rat tibiae and treated with LIPUS. The bone morphology around MSIs was evaluated by scanning electron microscopy and threedimensional micro-computed tomography. MC3T3-E1 cells cultured on Ti and SS discs were treated with LIPUS, and the temporary expression of alkaline phosphatase (ALP) was examined. Results. Bone-implant contact increased gradually from day 3 to day 14 after MSI insertion. LIPUS application increased the cortical bone density, cortical bone thickness, and cortical bone rate after implantation of Ti and SS MSIs (P < 0.05). LIPUS exposure induced ALP upregulation in MC3T3- E1 cells at day 3 (P < 0.05). Conclusion. LIPUS enhanced bone formation around Ti and SS MSIs, enhancing the initial stability of MSIs.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
• Related Material (DOI): 10.1016/j.archoralbio.2015.02.014
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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