Drug-induced interstitial pneumonia during perioperative chemotherapy for breast cancer

• Material Type: 博士論文
• Title: Drug-induced interstitial pneumonia during perioperative chemotherapy for breast cancer
• Author/Editor: Ikeuchi, Mayumi; Hino, Naoki; Nishisyo, Aya; Aoyama, Mariko; Kanematsu, Miyuki; Inoue, Hiroaki; Sasa, Soichiro; Inui, Tomohiro; Miyamoto, Naoki; Okumura, Kazumasa; Takizawa, Hiromitsu
• Author Heading: Ikeuchi, Mayumi; Hino, Naoki; Nishisyo, Aya; Aoyama, Mariko; Kanematsu, Miyuki; Inoue, Hiroaki; Sasa, Soichiro; Inui, Tomohiro; Miyamoto, Naoki; Okumura, Kazumasa; Takizawa, Hiromitsu
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2022-02
• Publication Date (W3CDTF): 2022-02
• Alternative Title: 乳癌周術期化学療法中に薬剤性間質性肺炎を発症した症例の検討; DIP during perioperative chemotherapy
• Periodical title: The Journal of Medical Investigation
• No. or year of volume/issue: 69 1-2
• Volume: 69
• Issue: 1-2
• Pages: 107-111
• ISSN (Periodical Title): ISSN : 1349-6867; ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2022-09-22
• Dissertation Number: 甲第3658号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: breast cancer; Drug-induced interstitial pneumonia; perioperative chemotherapy
• Target Audience: 一般
• Note (General): Purpose : Drug-induced interstitial pneumonia (DIP) that occurs during chemotherapy for breast cancer is a rare but a serious adverse event. Treatments of DIP requires interruption of breast cancer treatment, which may affect the patient’s prognosis. However, there are few reports which discuss DIP during breast cancer treatments. Purpose of this report is to make clear how DIP occurred and influenced breast cancer treatment in our hospital. Patients and Methods : A total of 74 patients who started perioperative chemotherapy in Tokushima Municipal Hospital for breast cancer from January 2019 to December 2020 were evaluated for DIP. Patients’ and tumors’ characteristics, and regimens which caused DIP were investigated. The clinical courses of the DIP patients were also followed up. Results : Twelve of the 74 patients developed DIP. All 12 patients had histories of cyclophosphamide administration ; however, the causative drug could not be determined. Ten of the 12 patients were treated with steroids, and all the patients recovered ultimately from the interstitial pneumonia. While chemotherapy was administered in six patients after mild DIP, no relapse of pneumonia was observed. Conclusion : DIP during perioperative chemotherapy for breast cancer was resolved with appropriate treatment. Patients were able to resume breast cancer treatment with minimal interruption.
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.69.107
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/117020/20221019163838895019/k3658_abstract.pdf fulltext

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