Rat Endothelial Cell Attachment, Behavior and Gene Expression on NaOH-treated Titanium Surfaces

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Rat Endothelial Cell Attachment, Behavior and Gene Expression on NaOH-treated Titanium Surfaces

Material type: 博士論文

Author: 中野, 容子

Publisher: Japanese Association of Regenerative Dentistry

Publication date: -

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: The aim of this study was to evaluate the influence of nanostructures on the surface of titanium, titanium nanosheets (TNS), on the initial a...

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Material Type: 博士論文
Title: Rat Endothelial Cell Attachment, Behavior and Gene Expression on NaOH-treated Titanium Surfaces
Author/Editor: 中野, 容子
Author Heading: 中野, 容子
Publication, Distribution, etc.: Japanese Association of Regenerative Dentistry
Alternative Title: 水酸化ナトリウム水溶液によりチタン表面に析出したナノ構造がラット血管内皮細胞の初期接着および遺伝子発現に与える影響について
Degree grantor/type: 大阪歯科大学
Date Granted: 2014-03-07
Dissertation Number: 甲第737号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: aortic endothelial cells
titanium
nanostructures
wound healing
Target Audience: 一般
Note (General): The aim of this study was to evaluate the influence of nanostructures on the surface of titanium, titanium nanosheets (TNS), on the initial attachment, proliferation, and gene expression of various functional factors by rat aortic endothelial cells (RAEC) involved in wound healing. We found that the initial attachment and proliferation of RAECs after 15, 30, 45, 60, and 120 min of culture were increased on titanium surfaces modified with TNS. We also found that the expression of intercellular adhesion molecule 1, von Willebrand, and thrombomodulin transcription factors were elevated in samples containing a TNS-modified disk in compared with unmodified titanium disks during the early stages of wound healing. Our results suggest that nanostructures on titanium surfaces stimulate RAECs to upregulate expression of angiogenic factors and adhesion molecule genes, which play an essential role in controlling inflammation and revascularization during wound healing after implantation.
2013
Source: fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=60&item_no=1&attribute_id=20&file_no=1
fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=60&item_no=1&attribute_id=20&file_no=2
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ