Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway

Material type: 博士論文

Author: 細山, 有規子

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: We examined the effect of gallotannin on osteoclast differentiation in vitro. We found that gallotannin suppressed osteoclast differentiation in a bon...

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Material Type: 博士論文
Title: Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway
Author/Editor: 細山, 有規子
Author Heading: 細山, 有規子
Alternative Title: 破骨細胞形成とp38 MAP kinase経路に対するGallotanninの影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2017-03-10
Dissertation Number: 甲第795号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: Osteoclast｜Gallotannin｜Tannin｜p38 MAP kinase｜NFATc1
Target Audience: 一般
Note (General): We examined the effect of gallotannin on osteoclast differentiation in vitro. We found that gallotannin suppressed osteoclast differentiation in a bone marrow culture system stimulated with 1, 25 (OH)2 D3, as well as in a M-CSF/RANKL-treated BMM culture system. Also, we found that gallotannin treatment suppressed the expression of NFATc1 in RANKL-treated BMMs. To further elucidate the mechanisms underlying the suppressive effect of gallotannin on osteoclast differentiation, we examined the effects of gallotannin on RANKL- and M-CSF-mediated intracellular signaling. Although gallotannin did not affect the activation kinetics of ERK1/2 and Akt, it blunted p38 MAPK activation in RANKL-treated BMMs. We also observed the suppressive effects of gallotannin on M-CSF-induced p38 MAPK activation in BMMs that had been programmed for osteoclast differentiation by pretreatment with RANKL and low-dose M-CSF for 24 h. In other words, gallotannin specifically suppressed RANKL- and M-CSF-induced activation of the p-38 MAPK pathway.
2016年度
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https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=153&item_no=1&attribute_id=20&file_no=1
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Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ