新世代アデノウイルスベクターとトランスポゼースによる進行性筋ジストロフィーの遺伝子治療

Material type: 文書・図像類

Author: 内野, 誠ほか

Publisher: 熊本大学

Publication date: 2008-03-31

Material Format: Digital

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Note (General)：: type:研究報告書Using HDAdv, we could treat DMD model mice, even when the therapeutic gene was transferred into multiple skeletal muscles. Our results sugge...

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Material Type: 文書・図像類
Title: 新世代アデノウイルスベクターとトランスポゼースによる進行性筋ジストロフィーの遺伝子治療
Author/Editor: 内野, 誠
Uchino, Makoto
Author Heading: 内野, 誠
Uchino, Makoto
Publication, Distribution, etc.: 熊本大学
Publication Date: 2008-03-31
Publication Date (W3CDTF): 2008-03-31
Alternative Title: シンセダイアデノウイルスベクタートトランスポゼースニヨルシンコウセイキンジストロフィーノイデンシチリョウ
Text Language Code: jpn
Subject Heading: dystrophin
hleper-dependent adenovirs
dkoマウス
multiple muscle injection
Sleeping Beauty transposon
dko mouse
nNOS
hepler-dependent adenovirus vector
genetherapy
Duchenne muscular dystrophy
DMD
mdx mouse
493.6
Target Audience: 一般
Note (General): type:研究報告書
Using HDAdv, we could treat DMD model mice, even when the therapeutic gene was transferred into multiple skeletal muscles. Our results suggest that multiple intramuscular administrations of HDAdv carrying full-length dystrophin may reduce symptoms and compensate for lost functions in DMD patients.For the long expression of target gene product, we tried to integrate the dystrophin gene into chromosome by using the sleeping beauty-transposone system and HDAdv. However, ito revealed that the DNA construct of HDAdv is linear and it does not fit the circular DNA of the sleeping buauty-transposone system. So, further study is necessary to integrate the dystrophin gene into chromosome.
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 熊本大学 : 熊本大学学術リポジトリ