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STAT5標的遺伝子による真性赤血球増加症発症機構の解析

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STAT5標的遺伝子による真性赤血球増加症発症機構の解析

Material type
文書・図像類
Author
多胡, めぐみ
Publisher
-
Publication date
2012
Material Format
Digital
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Note (General):

type:text真性赤血球増加症の原因遺伝子であるチロシンキナーゼJAK2の点変異体 (V617F)は、転写因子STAT5の活性化を介して細胞増殖や腫瘍形成を誘導する。本研究では、JAK2変異体の下流でSTAT5の活性化を介して、転写因子c-Mycおよびその標的遺伝子であるポリアミン合成酵素 OD...

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科研費研究者番号 : 30445192

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Material Type
文書・図像類
Author/Editor
多胡, めぐみ
Author Heading
Publication Date
2012
Publication Date (W3CDTF)
2012
Alternative Title
STAT5 ヒョウテキ イデンシ ニ ヨル シンセイ セッケッキュウ ゾウカショウ ハッショウ キコウ ノ カイセキ
STAT5 hyoteki idenshi ni yoru shinsei sekkekkyu zokasho hassho kiko no kaiseki
Analysis of the polycythemia vera onset mechanism by investigating STAT5-target genes
Periodical title
科学研究費補助金研究成果報告書
Text Language Code
jpn