梗塞後左室リモデリングの病態に関するマルチトレーサ生体分子イメージングの研究

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Author: 瀧, 淳一ほか

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Publication date: 2017-05-09

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Note (General)：: 金沢大学附属病院核医学診療科虚血再還流ラットにおけるI-125-抗tenascin-C抗体の集積を検討した結果、集積は３日でピークに達しその後漸減した。虚血直後のpostconditioningで集積は全経過を通して低下し左室リモデリングは抑制された。Tenascin-Cの間質での発現の抑制が2か月...

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Material Type: 文書・図像類
Title: 梗塞後左室リモデリングの病態に関するマルチトレーサ生体分子イメージングの研究
Author/Editor: 瀧, 淳一
Taki, Junichi
Author Heading: 瀧, 淳一
Taki, Junichi
Publication Date: 2017-05-09
Publication Date (W3CDTF): 2017-05-09
Alternative Title: Multi-tracer molecular imaging for the assessment of pathophysiology of ventricular remodeling after myocardial infarction
Periodical title: 平成28(2016)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 - 2017-03-31
Volume: 2014-04-01 - 2017-03-31
Pages: 5p.-
Text Language Code: jpn
Subject Heading: myocardial ischemia
remodeling
tenascin C
angiogenesis
RGD
apoptosis
annexin V
Target Audience: 一般
Note (General): 金沢大学附属病院核医学診療科
虚血再還流ラットにおけるI-125-抗tenascin-C抗体の集積を検討した結果、集積は３日でピークに達しその後漸減した。虚血直後のpostconditioningで集積は全経過を通して低下し左室リモデリングは抑制された。Tenascin-Cの間質での発現の抑制が2か月後の左室リモデリングの抑制に関連していることが考えられた。I-125-RGDの心筋梗塞後の集積の意義を検討した結果、7日から1月後では強い集積を認め、2月でやや低下した。集積は微小血管様構造にほぼ一致し、マクロファージの出現とは一致をみず、集積は血管新生を反映した。
Tenascin-C expression after myocardial ischemia and reperfusion was investigated using I-125-anti-tneascin-c-antibody (TNC). Autoradiography showed that the uptake peaked 3 days after reperfusion, followed by gradual reduction. Postconditioning at reperfusion suppressed TNC uptake at day 3 and thereafter and attenuated the left ventricular remodeling at 2 months later, suggesting that suppression of tenascin-C expression related to the attenuation of ventricular remodeling.αvβ3 integrin is expressed both by macrophages and angiogenic endothelial cells. We investigated whether I-125-RGD, which showed high affinity and selectivity for αvβ3, reflects inflammatory process or angiogenesis after myocardial infarction. I-125 RGD accumulated in the infarcted area, and its uptake corresponded closely to micro vessel formation rather than macrophage infiltrations until 2 months after infarction. RGD imaging may be useful for the evaluation of angiogenesis after myocardial infarction.
研究課題/領域番号:26461847, 研究期間(年度):2014-04-01 - 2017-03-31
DOI: 10.24517/00050610
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=10251927
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461847/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461847/26461847seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA