皮膚免疫疾患におけるＢ細胞抑制性受容体 CD22/72 の制御機構

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Author: 濱口, 儒人ほか

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Publication date: 2015-05-27

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Note (General)：: 金沢大学医薬保健研究域医学系本研究では、CD22とCD72を同時に欠損させたマウス（CD22-/-/CD72-/-マウス）を作成し、CD22とCD72の役割について検討した。CD22-/-/CD72-/-マウスでは野生型マウスに比べ末梢血液中における成熟B細胞の数が有意に減少していた。B細胞のtur...

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Material Type: 文書・図像類
Title: 皮膚免疫疾患におけるＢ細胞抑制性受容体 CD22/72 の制御機構
Author/Editor: 濱口, 儒人
Hamaguchi, Yasuhito
Author Heading: 濱口, 儒人
Hamaguchi, Yasuhito
Publication Date: 2015-05-27
Publication Date (W3CDTF): 2015-05-27
Alternative Title: A role of CD22 and CD72 in the immune responses
Periodical title: 平成26(2014)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2014 Fiscal Year Final Research Report
No. or year of volume/issue: 2012-04-01 - 2015-03-31
Volume: 2012-04-01 - 2015-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: B細胞
CD22
CD72
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
本研究では、CD22とCD72を同時に欠損させたマウス（CD22-/-/CD72-/-マウス）を作成し、CD22とCD72の役割について検討した。CD22-/-/CD72-/-マウスでは野生型マウスに比べ末梢血液中における成熟B細胞の数が有意に減少していた。B細胞のturnover 、血清免疫グロブリン濃度、T細胞依存あるいは非依存抗原に対する免疫応答は、それぞれの単独欠損マウスでみられる異常を越えるものではなかった。また、CD22-/-/CD72-/-マウスでは野生型マウスに比べ自己免疫疾患を発症しやすいことはなかった。以上より、CD22とCD72は独立してB細胞を制御していると考えられた。
In this study, we addressed whether CD22 and CD72 have redundant functions using CD22 and CD72 double-deficient (CD22-/-/CD72-/-) mice. CD22-/-/CD72-/- mice showed significantly decreased number of peripheral B cells compared to wild type mice. Turnover of B cells in CD22-/-/CD72-/- mice was significantly augmented than in wild type mice, but significantly reduced compared to CD22-/- mice. CD22-/- mice showed significantly increased serum IgM levels compared to wild type mice, but CD22-/-/CD72-/- mice did not. IgM responses against DNP-Ficoll were significantly decreased in CD22-/-/CD72-/- mice compared to wild type mice. In pristane-induced murine lupus model, both the incidence of ANAs and urine protein levels were similar between wild type and CD22-/-/CD72-/- mice. These results showed that abnormalities observed in CD22-/-/CD72-/- mice did not exceed the degree of those seen in each-deficient mice. Therefore, we concluded that CD22 and CD72 independently regulated B cell function.
研究課題/領域番号:24591645 , 研究期間(年度):2012-04-01 - 2015-03-31
DOI: 10.24517/00050812
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=44470&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=44470&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/search/?qm=60420329
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591645/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591645/24591645seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA