肺癌におけるcMetによるtopoisomeraseIの活性制御の解析

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Author: 笠原, 寿郎ほか

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Publication date: 2017-06-12

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Note (General)：: 金沢大学医薬保健研究域医学系肺癌における増殖因子受容体cMetと核内DNA複製酵素のTopoIの関連を検討した。１０種類の培養細胞を用いてcMetを検討したところ５細胞株でcMet高発現、リン酸化亢進を認めた。核内のTopoI発現、活性はcMet高発現細胞で高く活性も亢進しており、TopoI阻害剤の...

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Material Type: 文書・図像類
Title: 肺癌におけるcMetによるtopoisomeraseIの活性制御の解析
Author/Editor: 笠原, 寿郎
Kasahara, Kazuo
Author Heading: 笠原, 寿郎
Kasahara, Kazuo
Publication Date: 2017-06-12
Publication Date (W3CDTF): 2017-06-12
Alternative Title: Regulation of Topisomerase I activity by cMet in lung cancer
Periodical title: 平成28(2016)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 - 2017-03-31
Volume: 2014-04-01 - 2017-03-31
Pages: 5p.-
Text Language Code: jpn
Subject Heading: cMet
Topoisomerase I
Lung cancer
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
肺癌における増殖因子受容体cMetと核内DNA複製酵素のTopoIの関連を検討した。１０種類の培養細胞を用いてcMetを検討したところ５細胞株でcMet高発現、リン酸化亢進を認めた。核内のTopoI発現、活性はcMet高発現細胞で高く活性も亢進しており、TopoI阻害剤の感受性と関連していた。cMet阻害で、 TopoIも低下した。下流シグランルの検討では、TopoI発現に関連する２９の候補遺伝子を同定した。臨床検体を用いた解析で、cMetは37.7%、TopoIは51.3％で陽性を指名し、有意な相関を認めた。cMetがTopoI発現を調節している可能性が示唆され、治療戦略確立が期待される。
We examined the relationship between cMet and Topoisomerase I lung cancer. Protein expression and phosphorylation of cMet using 10 lung cancer cell lines revealed high expression and hyperphosphorylation in 5 cell line.Expression and activity of Topo I were higher in cMet overexpressing cells and were related to the sensitivity of Topo I inhibitors. Inhibition of cMet by Met inhibitor also decreased Topo I. Upon examination of the downstream signaling, 29 candidate genes associated with Topo I expression were identified by cMet stimulation and suppression. In analysis using clinical donation, cMet nominated positive with 37.7% and TopoI at 51.3%, showing a significant correlation. This study suggests that cMet may regulate the expression of Topo I and we believe that it will bring important findings to establish future treatment strategies.
研究課題/領域番号:26430159, 研究期間(年度):2014-04-01 - 2017-03-31
DOI: 10.24517/00050947
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=44606&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=44606&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/search/?qm=30272967
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430159/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430159/26430159seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA