Investigation of the therapeutic interaction of mesenchymal stem cells with glioblastoma stem-like cells and its biological mechanism

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Author: Pyko, Ilyaほか

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Publication date: 2018-09-11

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Note (General)：: 金沢大学がん進展制御研究所本研究は、膠芽腫(GBM)に対する間葉系幹細胞(MSCs)の作用を、GBM幹細胞(SCs)に対する効果およびテモゾロミド(TMZ)とGSK3β阻害剤との併用効果に着目して検討した。MSCsとGBM-SCsを共培養すると、GBM幹細胞形質が抑制された。GSK3β阻害剤は脂肪組...

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Material Type: 文書・図像類
Title: Investigation of the therapeutic interaction of mesenchymal stem cells with glioblastoma stem-like cells and its biological mechanism
Author/Editor: Pyko, Ilya
ピコ, イリア
Author Heading: Pyko, Ilya
ピコ, イリア
Publication Date: 2018-09-11
Publication Date (W3CDTF): 2018-09-11
Periodical title: 平成29(2017)年度科学研究費補助金若手研究(B) 研究成果報告書 = 2017 Fiscal Year Final Research Report
No. or year of volume/issue: 2016-04-01 - 2018-03-31
Volume: 2016-04-01 - 2018-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: glioblastoma
temozolomide
mesenchymal stem cells
GSK3β
Target Audience: 一般
Note (General): 金沢大学がん進展制御研究所
本研究は、膠芽腫(GBM)に対する間葉系幹細胞(MSCs)の作用を、GBM幹細胞(SCs)に対する効果およびテモゾロミド(TMZ)とGSK3β阻害剤との併用効果に着目して検討した。MSCsとGBM-SCsを共培養すると、GBM幹細胞形質が抑制された。GSK3β阻害剤は脂肪組織由来MSCsの患者由来GBM-SCsに対する治療的な細胞間相互作用を高めた。また、TMZとMSCの併用によるGBM治療効果を増強し、GBMマウスモデルの生存期間を延長した。以上の結果より、MSCsとGSK3β阻害剤の併用は有用なGBM治療法と考えられた。
We investigated whether mesenchymal stem cells (MSCs) transplantation benefits to treatment of glioblastoma (GBM) by enhancing anti-tumor effect in combination with GSK3β inhibitors and temozolomide (TMZ). We showed that MSCs co-cultured with GBM cells participate in regulation of GBM stem-like cell (SC) morphology. We examined the interaction between patient-derived GBM-SCs and adipose tissue-derived MSCs under GSK3β inhibition and TMZ and its influence on GBM-SCs. We found that combined treatment by GSK3β inhibitor enhanced therapeutic interaction of MSCs with GBM-SCs, and that combination of low-dose AR-A014418, TMZ and MSC treatment significantly reduced cell viability and showed anti-tumor effect against patient-derived GBM-SCs. Transplantation of MSCs and GSK3β inhibition improved survival in mouse GBM model.
研究課題/領域番号:16K19996, 研究期間(年度):2016-04-01 - 2018-03-31
出典：研究課題「Investigation of the therapeutic interaction of mesenchymal stem cells with glioblastoma stem-like cells and its biological mechanism」課題番号16K19996（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19996/16K19996seika/）を加工して作成
DOI: 10.24517/00055471
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=00731853
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19996/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19996/16K19996seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA