Investigation of the therapeutic interaction of mesenchymal stem cells with glioblastoma stem-like cells and its biological mechanism

Material type: 文書・図像類

Author: Pyko, Ilyaほか

Publisher: -

Publication date: 2018-09-11

Material Format: Digital

Capacity, size, etc.: -

NDC: -

View All

Notes on use

Note (General)：: 金沢大学がん進展制御研究所本研究は、膠芽腫(GBM)に対する間葉系幹細胞(MSCs)の作用を、GBM幹細胞(SCs)に対する効果およびテモゾロミド(TMZ)とGSK3β阻害剤との併用効果に着目して検討した。MSCsとGBM-SCsを共培養すると、GBM幹細胞形質が抑制された。GSK3β阻害剤は脂肪組...

Related materials as well as pre- and post-revision versions

https://kaken.nii.ac.jp/search/?qm=00731853

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19996/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19996/16K19996seika/

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Kanazawa University Repository for Academic Resources
Digital
You can check the holdings of institutions and databases with which 学術機関リポジトリデータベース（IRDB）（機関リポジトリ） is linked at the site of 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）.
Kanazawa University Repository for Academic Resources

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 文書・図像類
Title: Investigation of the therapeutic interaction of mesenchymal stem cells with glioblastoma stem-like cells and its biological mechanism
Author/Editor: Pyko, Ilya
ピコ, イリア
Author Heading: Pyko, Ilya
ピコ, イリア
Publication Date: 2018-09-11
Publication Date (W3CDTF): 2018-09-11
Periodical title: 平成29(2017)年度科学研究費補助金若手研究(B) 研究成果報告書 = 2017 Fiscal Year Final Research Report
No. or year of volume/issue: 2016-04-01 - 2018-03-31
Volume: 2016-04-01 - 2018-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: glioblastoma
temozolomide
mesenchymal stem cells
GSK3β
Target Audience: 一般
Note (General): 金沢大学がん進展制御研究所
本研究は、膠芽腫(GBM)に対する間葉系幹細胞(MSCs)の作用を、GBM幹細胞(SCs)に対する効果およびテモゾロミド(TMZ)とGSK3β阻害剤との併用効果に着目して検討した。MSCsとGBM-SCsを共培養すると、GBM幹細胞形質が抑制された。GSK3β阻害剤は脂肪組織由来MSCsの患者由来GBM-SCsに対する治療的な細胞間相互作用を高めた。また、TMZとMSCの併用によるGBM治療効果を増強し、GBMマウスモデルの生存期間を延長した。以上の結果より、MSCsとGSK3β阻害剤の併用は有用なGBM治療法と考えられた。
We investigated whether mesenchymal stem cells (MSCs) transplantation benefits to treatment of glioblastoma (GBM) by enhancing anti-tumor effect in combination with GSK3β inhibitors and temozolomide (TMZ). We showed that MSCs co-cultured with GBM cells participate in regulation of GBM stem-like cell (SC) morphology. We examined the interaction between patient-derived GBM-SCs and adipose tissue-derived MSCs under GSK3β inhibition and TMZ and its influence on GBM-SCs. We found that combined treatment by GSK3β inhibitor enhanced therapeutic interaction of MSCs with GBM-SCs, and that combination of low-dose AR-A014418, TMZ and MSC treatment significantly reduced cell viability and showed anti-tumor effect against patient-derived GBM-SCs. Transplantation of MSCs and GSK3β inhibition improved survival in mouse GBM model.
研究課題/領域番号:16K19996, 研究期間(年度):2016-04-01 - 2018-03-31
出典：研究課題「Investigation of the therapeutic interaction of mesenchymal stem cells with glioblastoma stem-like cells and its biological mechanism」課題番号16K19996（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19996/16K19996seika/）を加工して作成
DOI: 10.24517/00055471
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=49158&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=49158&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/search/?qm=00731853
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19996/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19996/16K19996seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA