慢性虚血性疼痛における各種成長因子の関与とその末梢感作機構の解明

Material type: 文書・図像類

Author: 堀, 紀代美ほか

Publisher: 金沢大学医薬保健研究域医学系

Publication date: 2019-05-24

Material Format: Digital

Capacity, size, etc.: -

NDC: -

View All

Notes on use

Note (General)：: 末梢動脈疾患（peripheral arterial disease :PAD）に伴う虚血性疼痛のメカニズムを解析するために、我々が開発したPADのモデル動物を用いて、下肢の虚血に起因する痛覚過敏に成長因子の神経成長因子(NGF)や血管内皮成長因子(VEGF)が関与するか検索した。SDラットの左下肢...

Related materials as well as pre- and post-revision versions

https://kaken.nii.ac.jp/search/?qm=40595443

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08668/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08668/15K08668seika/

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Kanazawa University Repository for Academic Resources
Digital
You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
Kanazawa University Repository for Academic Resources

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 文書・図像類
Title: 慢性虚血性疼痛における各種成長因子の関与とその末梢感作機構の解明
Author/Editor: 堀, 紀代美
Hori, Kiyomi
Author Heading: 堀, 紀代美
Hori, Kiyomi
Publication, Distribution, etc.: 金沢大学医薬保健研究域医学系
Publication Date: 2019-05-24
Publication Date (W3CDTF): 2019-05-24
Alternative Title: Nerve Growth Factor and Vascular Endothelial Growth Factor contribute to chronic ischemic pain in a rat model of peripheral arterial disease
Periodical title: 平成30(2018)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2018 Fiscal Year Final Research Report
No. or year of volume/issue: 2015-04-01 - 2019-03-31
Volume: 2015-04-01 - 2019-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 末梢動脈疾患
PAD
虚血性疼痛
筋痛
間欠性跛行
神経成長因子
血管内皮成長因子
Target Audience: 一般
Note (General): 末梢動脈疾患（peripheral arterial disease :PAD）に伴う虚血性疼痛のメカニズムを解析するために、我々が開発したPADのモデル動物を用いて、下肢の虚血に起因する痛覚過敏に成長因子の神経成長因子(NGF)や血管内皮成長因子(VEGF)が関与するか検索した。SDラットの左下肢への血流を阻害すると慢性の筋痛、間欠性跛行が認められた。虚血下肢筋でNGF量が増加し、NGFやVEGFの阻害は筋痛を抑制した。末梢動脈疾患における痛覚の亢進にはNGFやVEGFが重要と思われた。
AIM: To demonstrate neuronal mechanisms underlying ischemic pain with peripheral arterial disease (PAD), we investigated the role of NGF and VEGF on muscle hyperalgesia and intermittent claudication in a rat model of PAD. METHODS: We ligated the left common iliac and iliolumbar arteries completely. NGF and VEGF proteins in the gastrocnemius muscle (GM) were measured respectively. Effects of inhibitor of TrkA, a receptor of NGF, and VEGFR2, a receptor of VEGF were evaluated on behavioral responses. The expression of TrkA- and VEGFR2-receptor were examined in DRG neurons innervating GM. RESULT: We found muscle hyperalgesia and intermittent claudication after ligation. NGF protein level increased in GM and intramuscular injection of either TrkA- and VEGFR2-inhibitor suppressed muscle hyperalgesia in PAD rats. CONCLUSION:NGF and VEGF may play an important role in developing muscle hyperalgesia associated with PAD.
研究課題/領域番号:15K08668, 研究期間(年度):2015-04-01 - 2019-03-31
出典：研究課題「慢性虚血性疼痛における各種成長因子の関与とその末梢感作機構の解明」課題番号15K08668（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08668/15K08668seika/）を加工して作成
DOI: 10.24517/00054976
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=40595443
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08668/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08668/15K08668seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA