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- Material Type
- 文書・図像類
- Author/Editor
- 口岩, 聡
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- Kicking and biting behavioral responses toward mechanical touch stimuli in stress-disorder model mouse
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書 課題番号：21591487 研究代表者：口岩聡 (鹿児島大学大学院医歯学総合研究科准教授)多くの精神疾患患者においてイリタビリティ症状が発現するが、実験動物ではイリタビリティの解析技術は確立されていない。本研究では、まず、イリタビリティの行動学的症状とされる「接触逃避行動」と「対物攻撃行動」を計測する装置を開発した。次に、精神疾患モデルマウスを使用して、イリタビリティの検出および定量的評価法の確立を試み、向精神薬のイリタビリティ発現に対する影響を調査し、精神疾患モデルにおけるイリタビリティ症状の定量化技術を確立した。Irritability is a widely occurring DSM-IV symptom in patients with psychiatric disorders and/or developmental disorders. Behavioral symptoms of irritability also occur in laboratory psychiatric model animals such as stress and/or depression disorders. However, behavioral paradigms for estimation of irritability have not been reported in studies using laboratory animals. Establishment of protocols for estimation of irritability in psychiatric animal models is needed to study psychotropic drug evaluations. In the present study, we developed a new research apparatus that can detect and record intensities and incidence rates of touch escape behavior and aggressive behavior toward inanimate mechanical stimuli. We estimated irritability in chronically stressed mice and evaluated the effects of psychotropic drugs on irritability using the touch escape behavior and aggressive behaviors as paradigms. The present study suggests that both responses can be used as behavioral paradigms in quantitative analyses of irritability. Both paradigms appear to be useful for drug evaluation of psychotropic agents using the same individuals repeatedly.