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Bibliographic Record
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- Material Type
- 文書・図像類
- Author/Editor
- 吉満, 誠
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- Explication of organ specific pathogenesis in patients with cardiac Fabry disease using induced pluripotent stem cells
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2010-2011年度科学研究費助成事業(科学研究費補助金(若手研究(B)))研究成果報告書 課題番号：22790716 研究代表者：吉満誠 (鹿児島大学大学院医歯学総合研究科特任助教)心Fabry病患者の心臓特異的病態の解明を目的とした研究である。倫理委員会承認後に心Fabry病患者より線維芽細胞を採取し、レンチウイルス、レトロウイルスを用いた系でiPS細胞の樹立を試みた。健常者線維芽細胞からのiPS細胞樹立は容易であったが、心Fabry病患者からのiPS細胞樹立はできなかった。幹細胞へのリプログラミング過程におけるα-galactosidase Aの役割についてさらなる検討が必要である。The purpose of this study is to explicate organ specific pathogenesis in patients with cardiac Fabry disease using induced pluripotent stem cells. Upon approval of our local ethical committee, cardiac Fabry patient derived fibroblasts were established. Despite the success of establishment of iPS cells from healthy donor, we are not able to establish iPS cells from cardiac Fabry patient derived fibroblasts using lentiviral or retroviral reprogramming gene transduction. Further study is definitely required to reveal the role of defective enzyme alpha-galactosidase A in the process of reprogramming into iPS cells.