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Bibliographic Record
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- Material Type
- 文書・図像類
- Author/Editor
- 白藤, 梨可
- Author Heading
- 白藤, 梨可 シラフジ, リカ
- Publication, Distribution, etc.
- Alternative Title
- Study on the molecular mechanism of autophagy at nonfeeding periods in the hard tick Haemaphysalis longicornis
- Text Language Code
- jpn
- Subject Heading
- Target Audience
- 一般
- Note (General)
- 2009-2010年度科学研究費補助金(研究活動スタート支援)研究成果報告書 課題番号：21880038 研究代表者：白藤梨可 (鹿児島大学農学部プロジェクト研究員)獣医・医学上重要な吸血性節足動物マダニについて、数年に及ぶ生活史の大半を未吸血・飢餓状態で過ごすという性質に着目し、マダニの飢餓耐性を担う分子基盤の解明を実施した。未吸血マダニにおけるオートファジー関連遺伝子群の発現抑制ならびにオートファジー阻害剤処理により、実験群のマダニにおいて寿命が短縮した。このことから、宿主探索時のマダニはオートファジーを活用して栄養分を補い、飢餓に耐えていることが示唆された。Ticks are hematophagous arthropods and they can survive without food during the host-seeking period for several months to years. This study focused on autophagy which is induced during starvation in eukaryotes. Knockdown of autophagy-related genes and treatment with autophagy inhibitor led to a shortened life span in adult ticks. Tick autophagy might help compensate for the loss of nutrients derived from host blood components during the non-feeding period.