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博士論文

Phosphodiester Hydrolysis by a New Zinc(II) Macrocyclic Tetraamine Complex with an Alcohol Pendant : Elucidation of the Roles of Ser-102 and Zinc(II) in Alkaline Phosphatase

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Phosphodiester Hydrolysis by a New Zinc(II) Macrocyclic Tetraamine Complex with an Alcohol Pendant : Elucidation of the Roles of Ser-102 and Zinc(II) in Alkaline Phosphatase

Material type
博士論文
Author
児玉, 頼光
Publisher
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Publication date
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Material Format
Digital
Capacity, size, etc.
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Name of awarding university/degree
広島大学,博士(薬学),Pharmacology
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アルカリホスファターゼ(AP)は、リン酸モノエステルの加水分解やリン酸転移反応を触媒する亜鉛酵素であり、その活性中心は2つの亜鉛イオンとそれらを固定するアミノ酸残基および亜鉛イオン近傍のセリン残基とから構成されている。現在、この酵素の反応機構として、リン酸モノエステルのリン酸がセリン残基に転移したホ...

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  • 論文要旨 Contents Abstract / p1 1.Introduction / p2 2.Results and Discution / p5 　2-1.Synthesis of Benzyl Alcohol-Pendant Cyclen / p5 　2-2.Protonation and Zinc(II)Complexation Constants of the Benzyl Alcohol-Pendant Cyclen / p5 　2-3.X-ray Crystal Structure of the ZnII Complex of the Deprotonated Benzyl Alcohol-Pendant Cyclen / p7 　2-4.Net Reaction of the Benzyl Alcohol-Pendant Cyclen-ZnII Complex with Bis(4-nitrophenyl)Phosphate / p10 　2-5.A Kinetic Study of the Initial Reaction / p12 　2-6.Isolation of the Phosphoryl Intermediate / p14 　2-7.Spontaneous Hydrolysis of the Pendant Phosphodiester in the Phosphoryl Intermediate to a Phosphomonoester by the Intramolecular ZnII-OH⁻ / p14 　2-8.Hydrolysis of Ethyl(4-Nitrophenyl)Phosphate with an Intermolecular Nucleophile ZnII-OH⁻ / p16 3.Summary and Conclusions / p17 4.Experimental Section / p18 References and Notes / p23 Acknowledgement / p25

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    Hiroshima University Institutional Repository

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Material Type
博士論文
Title
Phosphodiester Hydrolysis by a New Zinc(II) Macrocyclic Tetraamine Complex with an Alcohol Pendant : Elucidation of the Roles of Ser-102 and Zinc(II) in Alkaline Phosphatase
Author/Editor
児玉, 頼光
Author Heading
児玉, 頼光
Alternative Title
大環状テトラアミン亜鉛錯体を用いたリン酸エステルの加水分解 : アルカリホスファタ-ゼにおける亜鉛イオンとセリン残基の役割
Degree grantor/type
広島大学
Date Granted
1996-03-26
Dissertation Number
甲第1487号
Degree Type
博士(薬学)
Pharmacology
Text Language Code
eng