Differentiation of Apical Bud Cells in a Newly Developed Apical Bud Transplantation Model Using GFP Transgenic Mice as Donor.

• Material Type: 博士論文
• Title: Differentiation of Apical Bud Cells in a Newly Developed Apical Bud Transplantation Model Using GFP Transgenic Mice as Donor.
• Author/Editor: Maruo, Naoki; Sakagami, Ryuji; Yoshinaga, Yasunori; Okamura, Kazuhiko; Sawa, Yoshihiko
• Author Heading: Maruo, Naoki; Sakagami, Ryuji; Yoshinaga, Yasunori; Okamura, Kazuhiko; Sawa, Yoshihiko
• Publication Date: 2016-03-12
• Publication Date (W3CDTF): 2016-03-12
• Alternative Title: Differentiation of Apical Bud Cells in a Newly Developed Apical Bud Transplantation Model Using GFP Transgenic Mice as Donor.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2016-03-12
• Date Granted (W3CDTF): 2016-03-12
• Dissertation Number: 甲第278号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第278号
• Text Language Code: eng
• Subject Heading: apical bud; cervical loop; 歯の移植; 齧歯類切歯; 上皮間葉転換; tooth transplantation; rodent incisor; epithelial‐mesenchymal transition
• Target Audience: 一般
• Note (General): Rodent mandibular incisors have a unique anatomical structure that allows teeth to grow throughout the lifetime of the rodent. This report presents a novel transplantation technique for studying the apical bud differentiation of rodent mandibular incisors. Incisal apical end tissue with green fluorescent protein from transgenic mouse was transplanted to wild type mice, and the development of the transplanted cells were immunohistologically observed for 12 weeks after the transplantation. Results indicate that the green fluorescent apical end tissue replaced the original tissue, and cells from the apical bud differentiated and extended toward the incisal edge direction. The immunostaining with podoplanin also showed that the characteristics of the green fluorescent tissue were identical to those of the original. The green fluorescent cells were only found in the labial side of the incisor up to 4 weeks. After 12 weeks, however, they were also found in the lingual side. Here the green fluorescent cementocyte-like cells were only present in the cementum close to the dentin surface. This study suggests that some of the cells that form the cellular cementum come from the apical tissue including the apical bud in rodent incisors.; PLoS One. 2016 Mar 15;11(3):e0150766. doi: 10.1371/journal.pone.0150766. eCollection 2016.; PLOS ONE
• Persistent ID (NDL): info:ndljp/pid/10120915; https://dl.ndl.go.jp/pid/10120915
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-07-07T04:28:02+09:00
• Date Created (W3CDTF): 2016-06-02
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): PLoS One. 2016 Mar 15;11(3):e0150766. doi: 10.1371/journal.pone.0150766. eCollection 2016.; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150766
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/63
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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