Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis 5

• Material Type: 博士論文
• ISSN: 0013-7227
• Title: Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis
• Volume: 157 5
• Author/Editor: Nikitski, Alyaksandr
• Author Heading: Nikitski, Alyaksandr
• Publication, Distribution, etc.: Endocrine Society
• Publication Date: 2016-06-01
• Publication Date (W3CDTF): 2016-06-01
• Alternative Title: 甲状腺にFoxe1を過剰発現するマウスでは、多結節性甲状腺腫を来すが、発癌は促進しない
• Periodical title: Endocrinology
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2016-06-01
• Date Granted (W3CDTF): 2016-06-01
• Dissertation Number: 甲医歯薬第875号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第875号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Recent genome-wide association studies have identified several single nucleotide polymorphisms in the forkhead box E1 gene (FOXE1) locus, which are strongly associated with the risk for thyroid cancer. In addition, our recent work has demonstrated FOXE1 overexpression in papillary thyroid carcinomas. To assess possible contribution of Foxe1 to thyroid carcinogenesis, transgenic mice overexpressing Foxe1 in their thyroids under thyroglobulin promoter (Tg-Foxe1) were generated. Additionally, Tg-Foxe1 mice were exposed to x-rays at the age of 5 weeks or crossed with Pten+/- mice to examine the combined effect of Foxe1 overexpression with radiation or activated phosphatidylinositol-3-kinase/Akt pathway, respectively. In 5- to 8-week-old Tg-Foxe1 mice, severe hypothyroidism was observed, and mouse thyroids exhibited hypoplasia of the parenchyma. Adult 48-week-old mice were almost recovered from hypothyroidism, their thyroids were enlarged, and featured colloid microcysts and multiple benign nodules of macrofollicular-papilloid growth pattern, but no malignancy was found. Exposure of transgenic mice to 1 or 8 Gy of x-rays and Pten haploinsufficiency promoted hyperplastic nodule formation also without carcinogenic effect. These results indicate that Foxe1 overexpression is not directly involved in the development of thyroid cancer and that proper Foxe1 dosage is essential for achieving normal structure and function of the thyroid.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第875号 学位授与年月日:平成28年6月1日; Author: Alyaksandr Nikitski, Vladimir Saenko, Mika Shimamura, Masahiro Nakashima, Michiko Matsuse, Keiji Suzuki, Tatiana Rogounovitch, Tetiana Bogdanova, Nobuyuki Shibusawa, Masanobu Yamada, Yuji Nagayama, Shunichi Yamashita, Norisato Mitsutake; Citation: Endocrinology, 157(5), pp.2182-2195; 2016; Nagasaki University (長崎大学), 博士(医学) (2016-06-01)
• DOI: info:doi/10.1210/en.2015-2066; https://doi.org/info:doi/10.1210/en.2015-2066
• Persistent ID (NDL): info:ndljp/pid/10120995; https://dl.ndl.go.jp/pid/10120995
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-07-07T04:28:02+09:00
• Date Created (W3CDTF): 2020-12-21
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10069/36579; https://nagasaki-u.repo.nii.ac.jp/records/3417
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2021-03-07 再収集