Histological characteristics of the myometrium in the postpartum hemorrhage of unknown etiology −A possible involvement of local immune reactions−

• Material Type: 博士論文
• Title: Histological characteristics of the myometrium in the postpartum hemorrhage of unknown etiology −A possible involvement of local immune reactions−
• Volume: 110
• Author/Editor: Farhana, Mustari
• Author Heading: Farhana, Mustari
• Publication, Distribution, etc.: ELSEVIER
• Publication Date: 2015
• Publication Date (W3CDTF): 2015
• Alternative Title: 原因不明の後産期出血症例における子宮体部筋層の組織学的特徴 −局所免疫応答の関与の可能性について−
• Periodical title: Journal of reproductive immunology
• Degree grantor/type: 浜松医科大学
• Date Granted: 2015-06-19
• Date Granted (W3CDTF): 2015-06-19
• Dissertation Number: 甲第706号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 13802甲第706号
• Text Language Code: eng
• Subject Heading: pregnancy; postpartum hemorrhage (PPH); uterine atony; myometritis; amniotic fluid embolism
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; The aim of this study was to evaluate the histological characteristics of the myometrium obtained on postpartum hemorrhage (PPH) of unknown etiology secondary to uterine atony. They were selected among registered cases of clinically suspected amniotic fluid embolism (AFE) and classified as PPH of unknown etiology because of no obvious cause of PPH at Hamamatsu University School of Medicine, a registration center for clinical AFE in Japan. Immunohistochemical studies were done on myometrium using anti-mast cell tryptase, anti-neutrophil elastase, anti-CD68, anti-CD88, anti-CD3, and anti-ZnCP-1 antibodies. Massive infiltrations of inflammatory cells with mast cell degranulation within the myometrium secondary to complement activation were observed in PPH of unknown etiology (n=34), but not in control pregnant women (n=15) or after delivery women without PPH (n=18). The concomitant immunohistochemical detection of meconium in myometrium suggests that amniotic fluids or fetal materials are one of the candidates to induce maternal local immune activation in the PPH of unknown etiology. Postpartum acute myometritis in the absence of an infective etiology may be a histological characteristic of PPH of unknown etiology.
• DOI: 10.1016/j.jri.2015.04.004; https://doi.org/10.1016/j.jri.2015.04.004
• Persistent ID (NDL): info:ndljp/pid/10121010; https://dl.ndl.go.jp/pid/10121010
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-07-07T04:28:02+09:00
• Date Created (W3CDTF): 2018-08-27
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/3031; https://hama-med.repo.nii.ac.jp/records/2892
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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