Effects of Decreased Occlusal Loading during Growth on the Mandibular Bone Characteristics 6

• Material Type: 博士論文
• ISSN: 1932-6203
• Title: Effects of Decreased Occlusal Loading during Growth on the Mandibular Bone Characteristics
• Volume: 10 6
• Author/Editor: Hichijo, Natsuko; Tanaka, Eiji; Kawai, Nobuhiko; Ruijven, Leo J. van; Langenbach, Geerling E. J.
• Author Heading: Hichijo, Natsuko; Tanaka, Eiji; Kawai, Nobuhiko; Ruijven, Leo J. van; Langenbach, Geerling E. J.
• Publication, Distribution, etc.: PLOS
• Publication Date: 2015-06-10
• Publication Date (W3CDTF): 2015-06-10
• Alternative Title: 成長期における咀嚼性刺激の減少が下顎骨の性状に及ぼす影響; Effects of Decreased Loading on the Mandible
• Periodical title: PLOS ONE
• Degree grantor/type: 徳島大学
• Date Granted: 2016-03-23
• Date Granted (W3CDTF): 2016-03-23
• Dissertation Number: 甲第2939号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第2939号
• Text Language Code: eng
• Subject Heading: muscle activity; loading stimulus; bone remodeling; mineralization
• Target Audience: 一般
• Note (General): BackgroundBone mass and mineralization are largely influenced by loading. The purpose of this study was to evaluate the reaction of the entire mandibular bone in response to decreased load during growth. It is hypothesized that decreased muscular loading will lead to bone changes as seen during disuse, i.e. loss of bone mass.Methods and FindingsTen 21-day-old Wistar strain male rats were divided into two groups (each n=5) and fed on either a hard- or soft-diet for 11 weeks. Micro-computed tomography was used for the investigation of bone mineralization, bone volume, bone volume fraction (BV/TV) and morphological analysis. Mandibular mineralization patterns were very consistent, showing a lower degree of mineralization in the ramus than in the corpus. In the soft-diet group, mineralization below the molars was significantly increased (p<0.05) compared to the hard diet group. Also, bone volume and BV/TV of the condyle and the masseter attachment were decreased in the soft-diet group (p<0.05). Morphological analysis showed inhibited growth of the ramus in the soft-diet group (p<0.05).ConclusionDecreased loading by a soft diet causes significant changes in the mandible. However, these changes are very region-specific, probably depending on the alterations in the local loading regime. The results suggest that muscle activity during growth is very important for bone quality and morphology.
• DOI: info:doi/10.1371/journal.pone.0129290; https://doi.org/info:doi/10.1371/journal.pone.0129290
• Persistent ID (NDL): info:ndljp/pid/10121622; https://dl.ndl.go.jp/pid/10121622
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-07-07T04:28:02+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://repo.lib.tokushima-u.ac.jp/109704
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp