Polyphosphate Derived from Lactobacillus brevis Inhibits Colon Cancer Progression Through Induction of Cell Apoptosis

Persistent ID (NDL): info:ndljp/pid/10164829

Material type: 博士論文

Author: 坂谷, 慧

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Publication date: 2016-02

Material Format: Digital

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Name of awarding university/degree: 旭川医科大学,博士（医学）

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Note (General)：: Although probiotics are known to have antitumor activity, few bacteria-derived antitumor molecules have been identified. The present study explored an...

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Material Type: 博士論文
ISSN: 0250-7005
Title: Polyphosphate Derived from Lactobacillus brevis Inhibits Colon Cancer Progression Through Induction of Cell Apoptosis
Volume: 36 2
Author/Editor: 坂谷, 慧
Publication Date: 2016-02
Publication Date (W3CDTF): 2016-02
Periodical title: Anticancer research
Degree grantor/type: 旭川医科大学
Date Granted: 2016-06-30
Date Granted (W3CDTF): 2016-06-30
Dissertation Number: 甲第497号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第497号
Text Language Code: eng
Subject Heading: Colon cancer
ERK
antitumor effect
apoptosis
polyphosphate
probiotics
Note (General): Although probiotics are known to have antitumor activity, few bacteria-derived antitumor molecules have been identified. The present study explored an antitumor molecule derived from Lactobacillus brevis SBL8803 (L. brevis 8803) and the mechanisms that underlie its effects. Cell viability and apoptosis were assessed by a sulforhodamine B assay and terminal deoxynucleotidyl transferase dUTP staining, respectively. Phosphorylated extracellular signal-regulated kinase (ERK) and cleaved poly ADP-ribose polymerase (PARP) expression were detected by western blotting. The conditioned medium of L. brevis 8803 inhibited SW620 cells viability and the effect was reduced by the degradation of polyphosphate (poly P) in the conditioned medium. A xenograft model showed that poly P inhibited the growth of SW620 cells. Poly P induced the apoptosis of SW620 cells through activation of the ERK pathway. In contrast, in primary cultured cells derived from normal mouse, poly P did not affect cell viability. Probiotic-derived poly P is expected to be an antitumor drug with fewer adverse effects than conventional drugs.
identifier:PMID:26851013
開始ページ : 591
終了ページ : 598
Persistent ID (NDL): info:ndljp/pid/10164829
https://dl.ndl.go.jp/pid/10164829
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Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2016-08-02T06:56:17+09:00
Format (IMT): application/pdf
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20160630K497
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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