ラット肝臓の損傷された組織と正常な腹膜の間に形成される術後癒着に関する形態学的研究

Persistent ID (NDL): info:ndljp/pid/10200460

Material type: 博士論文

Author: 鈴木, 達也

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Publication date: 2015-01

Material Format: Digital

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Name of awarding university/degree: 旭川医科大学,博士（医学）

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Note (General)：: The pathophysiology of adhesion formation needs to be clarified to reduce the adhesion-related morbidity. The epithelial characteristics of the perito...

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Material Type: 博士論文
Title: ラット肝臓の損傷された組織と正常な腹膜の間に形成される術後癒着に関する形態学的研究
Volume: 8 5
Author/Editor: 鈴木, 達也
Publication Date: 2015-01
Publication Date (W3CDTF): 2015-01
Alternative Title: A morphological study of postoperative adhesions between injured tissue and intact peritoneum in the rat liver
Periodical title: Scientific Reports
Degree grantor/type: 旭川医科大学
Date Granted: 2014-03-25
Date Granted (W3CDTF): 2014-03-25
Dissertation Number: 甲第453号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第453号
Text Language Code: eng
Note (General): The pathophysiology of adhesion formation needs to be clarified to reduce the adhesion-related morbidity. The epithelial characteristics of the peritoneum suggest a protective role against adhesion formation, yet how the peritoneum is involved in adhesion formation is not well characterized. We microscopically observed an experimental model of adhesion formation to investigate the effects of an injured tissue on the opposite intact peritoneum. Adhesions were induced between injured and intact hepatic lobes, and the intact peritoneum opposite to the injured tissue was examined for 8 days. The opposite intact peritoneum was denuded of mesothelial cells for 6 hours, and the remnant mesothelial cells changed morphologically for 24 hours. The detachment of mesothelial cells allowed fibrin to attach to the basement membrane of the opposite peritoneum, connecting the two lobes. Moreover, macrophages and myofibroblasts accumulated between the two lobes, and angiogenesis occurred from the opposite intact lobe to the injured lobe. These observations indicate that an injured tissue deprives the opposite intact peritoneum of its epithelial structure and causes fibrous adhesions to the opposite intact tissue. This study implies a possible role of mesothelial cells for barrier function against adhesion formation, that is, keeping mesothelial cells intact might lead to its prophylaxis.
identifier:PMID:25566876
DOI: info:doi/10.1038/srep07668
https://doi.org/info:doi/10.1038/srep07668
Persistent ID (NDL): info:ndljp/pid/10200460
https://dl.ndl.go.jp/pid/10200460
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2016-10-01T18:16:16+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Periodical Title (URI): http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20140325_K453
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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