A Combination Polymorphism of the Glutathione Synthesis Genes Can Be a Predictive Biomarker for Anti-Tuberculosis Drug-Induced Hepatotoxicity in Japanese Patients with Pulmonary Tuberculosis 2

• Material Type: 博士論文
• ISSN: 2472-1018
• Title: A Combination Polymorphism of the Glutathione Synthesis Genes Can Be a Predictive Biomarker for Anti-Tuberculosis Drug-Induced Hepatotoxicity in Japanese Patients with Pulmonary Tuberculosis
• Volume: 2 2
• Author/Editor: 馬渡, 力
• Author Heading: 馬渡, 力
• Publication, Distribution, etc.: OMICS International
• Publication Date: 2016-09-07
• Publication Date (W3CDTF): 2016-09-07
• Alternative Title: グルタチオン合成関連遺伝子の多型の組み合わせは日本人肺結核患者における抗結核薬誘発性肝障害の予測バイオマーカーとなり得る
• Periodical title: Journal of Lung Diseases & Treatment
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2016-09-07
• Date Granted (W3CDTF): 2016-09-07
• Dissertation Number: 甲医歯薬第887号
• Degree Type: 博士(薬学)
• Conferring No. (Dissertation): 甲医歯薬第887号
• Text Language Code: eng
• Subject Heading: Tuberculosis; Anti-tuberculosis drug-induced hepatotoxicity; Single nucleotide polymorphism; Glutathione synthesis; Case-control association study
• Target Audience: 一般
• Note (General): Background: To identify certain genes related to anti-tuberculosis drug-induced hepatotoxicity (ATDH) for Japanese patients with pulmonary tuberculosis (TB), we examined an association study of single nucleotide polymorphisms (SNPs) in candidate genes in glutathione synthesis with susceptibility to ATDH. Method: We studied 100 TB patients treated with anti-TB drugs. The frequencies of alleles and genotypes of 17 tag SNPs in 3 genes between TB patients with and without ATDH were compared by chi-square test or Fisher's exact test in three different inheritance models. A genetic testing was carried out using a single or combination of the associated SNP(s) as a biomarker. Results: Statistical analyses indicated that a C/C genotype of rs553822 in glutamate cysteine ligase, catalytic subunit (GCLC) and an A/T or T/T genotype of rs12140446 in glutamate cysteine ligase, modifier subunit (GCLM) independently contributed to susceptibility to ATDH. Genetic testing showed that the TB patients without these polymorphisms of GCLC and GCLM could safely be treated with anti-TB drugs on the basis of the higher value for the specificity and negative predictive value. Conclusion: GCLC and GCLM are ATDH-related genes and may be useful as a new biomarker to predict the high-risk TB patients susceptible to ATDH.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第887号 学位授与年月日:平成28年9月7日; Author: Mawatari T, Yoshida E, Higuchi N, Sato K, Inamine T, Kondo S, Fukushima K, Suyama N, Mukae H, Kohno S, Tsukamoto K; Citation: Journal of Lung Diseases & Treatment, 2(2), 1000105; 2016; Nagasaki University (長崎大学), 博士(薬学) (2016-09-07)
• DOI: info:doi/10.4172/2472-1018.1000105; https://doi.org/info:doi/10.4172/2472-1018.1000105
• Persistent ID (NDL): info:ndljp/pid/10200790; https://dl.ndl.go.jp/pid/10200790
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-10-01T18:16:16+09:00
• Date Created (W3CDTF): 2020-12-21
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10069/36832; https://nagasaki-u.repo.nii.ac.jp/records/3658
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2021-03-07 再収集