Protective effects of (6R)-5,6,7,8-tetrahydro-l-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva

• Material Type: 博士論文
• Title: Protective effects of (6R)-5,6,7,8-tetrahydro-l-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva
• Author/Editor: 田中, 優作; Tanaka, Yusaku
• Author Heading: 田中, 優作; Tanaka, Yusaku
• Publication Date: 2016-03-17
• Publication Date (W3CDTF): 2016-03-17
• Alternative Title: ラット歯肉における局所虚血／再灌流誘発性反応性充血の抑制に対する(6R)-5,6,7,8-tetrahydro-L-biopterinの防御効果
• Degree grantor/type: 神奈川歯科大学
• Date Granted: 2016-03-17
• Date Granted (W3CDTF): 2016-03-17
• Dissertation Number: 甲第482号
• Degree Type: 博士（臨床歯学）
• Conferring No. (Dissertation): 甲第482号
• Text Language Code: eng
• Subject Heading: BH4; gingiva; nitric oxide synthases; reactive hyperemia; reperfusion
• Target Audience: 一般
• Note (General): 2015; application/pdf; We herein investigated the regulatory mechanism in the circulation responsible for rat gingival reactive hyperemia (RH) associated with ischemia/reperfusion (I/R). RH was analyzed using a laser Doppler flowmeter. RH and I/R were elicited by gingival compression and release with a laser Doppler probe. RH increased in a time-dependent manner when the duration of compression was between 30s and 20min. This increase was significantly suppressed by N (ω)-nitro-l-arginine-methyl-ester (l-NAME), 7-nitroindazole (7-NI), and 2,4-diamino-6-hydroxypyrimidine (DAHP). However, RH was markedly inhibited following 60min of compression. This inhibition was significantly decreased by treatments with superoxide dismutase (SOD), (6R)-5,6,7,8-tetrahydro-l-biopterin (BH4), and sepiapterin. The luminescent intensity of superoxide anion (O2 (•-))-induced 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo-[1,2-a] pyrazine-3-one (MCLA) was markedly decreased by SOD and BH4, but only slightly by sepiapterin. BH4 significantly decreased O2 (•-) scavenging activity in a time-dependent manner. These results suggested that nitric oxide (NO) secreted by the nitrergic nerve played a role in regulating local circulation in rat gingiva. This NO-related regulation of local circulation was temporarily inhibited in the gingiva by the I/R treatment. The decrease observed in the production of NO, which was caused by suppression of NO synthase (NOS) activity subsequent to depletion of the NOS co-factor BH4 by O2 (•-), played a partial role in this inhibition.; Journal of Clinical Biochemistry and Nutrition, 58(1):69-75, 2016.1. doi: 10.3164/jcbn.15-69; J-STAGE
• Persistent ID (NDL): info:ndljp/pid/10211216; https://dl.ndl.go.jp/pid/10211216
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-11-02T12:02:18+09:00
• Date Created (W3CDTF): 2016-07-06
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): Journal of Clinical Biochemistry and Nutrition, 58(1):69-75, 2016.1. doi: 10.3164/jcbn.15-69; https://www.jstage.jst.go.jp/article/jcbn/58/1/58_15-69/_article
• Periodical Title (URI): https://kdu.repo.nii.ac.jp/records/948
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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