Notch as a Possible Cell Differentiation Factor in Pleomorphic Adenomas

• Material Type: 博士論文
• ISSN: 1449-1907
• Title: Notch as a Possible Cell Differentiation Factor in Pleomorphic Adenomas
• Volume: 12 10
• Author/Editor: Takamine, Keisuke; Ueda, Yukiko; Nakano, Keisuke; Ochiai, Takanaga; Sugita, Yoshihiko; Kubo, Katsutoshi; Mada, Hatsuhiko; Hasegawa, Hiromasa; Kawakami, Toshiyuki; 高峰, 圭介
• Publication Date: 2015-09-05
• Publication Date (W3CDTF): 2015-09-05
• Alternative Title: 多形腺腫における細胞分化因子としてのNotchの可能性
• Periodical title: International Journal of Medical Sciences
• Degree grantor/type: 松本歯科大学
• Date Granted: 2016-02-05
• Date Granted (W3CDTF): 2016-02-05
• Dissertation Number: 甲第183号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第183号
• Text Language Code: eng
• Subject Heading: Notch1; pleomorphic adenoma; cell differentiation; immunohistochemistry
• Note (General): The expression of Notch in 30 cases of pleomorphic adenoma was examined by immunohistochemistry.Comparing the results of our study with previous literatures, from the partial CK7 expression and substantial Notch expression in ductal epithelial cells as well as the Notch expression in solid tumor nests, it can be inferred that Notch is involved in cell differentiation. CK13 expression was observed in cells undergoing squamous metaplasia and Notch expression was seen in the nucleus of basal and squamous cells. The intense Notch expression in basal cells and weak expression in squamous cells suggests that Notch is involved in the differentiation from basal to squamous cell. Moreover, the loss of nuclear expression on the inner layer would signify that differentiation is about to end or has been terminated. Notch was expressed in the cytoplasm of cartilage cells and in the cell membrane of mucous cells but not in the nucleus indicating that differentiation has been concluded. Notch involvement is suspected in cell differentiation in areas showing ductal structures and squamous metaplasia. In summary, Notch is involved in cell differentiation of ductal cells in PA. Nuclear expression was shown in tumor cells in solid nests and surrounding structures. Moreover, Notch is expressed by basal cells undergoing squamous metaplasia suggesting the participation of Notch in cell differentiation in PA.; 2015; identifier:甲第183号; PubMed番号 : 26516303; 元資料の権利情報 : © 2015 Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License.(https://creativecommons.org/licenses/by-nc/4.0/); 元資料の権利情報 : CC BY-NC-ND; 開始ページ : 759; 終了ページ : 763
• DOI: info:doi/10.7150/ijms.12882; https://doi.org/info:doi/10.7150/ijms.12882
• Persistent ID (NDL): info:ndljp/pid/10211285; https://dl.ndl.go.jp/pid/10211285
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-11-02T12:02:18+09:00
• Date Created (W3CDTF): 2016-06-02
• Format (IMT): PDF
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• Original Material (URI): 雑誌掲載論文(電子版); http://www.medsci.org/v12p0759.htm; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615235/
• Periodical Title (URI): http://id.nii.ac.jp/1070/00002504/
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp