The Level of Bone Marrow WT1 Message is a Useful Marker to Differentiate Myelodysplastic Syndromes with Low Blast Percentage from Cytopenia due to Other Reasons

• Material Type: 博士論文
• ISSN: 0918-2918
• Title: The Level of Bone Marrow WT1 Message is a Useful Marker to Differentiate Myelodysplastic Syndromes with Low Blast Percentage from Cytopenia due to Other Reasons
• Volume: 54 5
• Author/Editor: 馬場, 真紀
• Author Heading: 馬場, 真紀
• Publication, Distribution, etc.: 日本内科学会
• Publication Date: 2016-10-05
• Publication Date (W3CDTF): 2016-10-05
• Alternative Title: 骨髄中のWT1発現量の測定は、芽球比率の低い骨髄異形成症候群とその他の理由による血球減少症との鑑別に有用である。
• Periodical title: Internal Medicine
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2016-10-05
• Date Granted (W3CDTF): 2016-10-05
• Dissertation Number: 甲医歯薬第897号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第897号
• Text Language Code: eng
• Subject Heading: myelodysplastic syndromes; WT1; cytopenia; IPSS; IPSS-R
• Target Audience: 一般
• Note (General): Objective: Myelodysplastic syndromes (MDS) are a group of hematological neoplasms associated with ineffective hematopoiesis and that transform to acute leukemia. Distinguishing MDS from other cytopenias is sometimes difficult even for trained hematologists. WT1, the gene mutated in Wilms' tumor, was found expressed in acute myeloid leukemia and MDS. The amount of WT1 in peripheral blood and bone marrow (BM) is low in low-risk MDS subtypes, and is high in high-risk MDS subtypes. However, the role of WT1 in the differential diagnosis between MDS and other diseases showing cytopenia has not been fully addressed. The present study evaluated whether WT1 expression level can assist in the differential diagnosis of MDS from other cytopenias. Methods: The amount of WT1 message was evaluated among 56 MDS patients and 47 patients with cytopenia for various other reasons (cytopenia VR) at the Nagasaki University Hospital. Results: The level of WT1 was significantly related to the percentage of blasts in BM among MDS cases, and the type of French-American-British classification of MDS; refractory anemia (RA) cases showed significantly lower WT1 level than patients with RA with excess blasts. WT1 level was significantly related to the prognostic risk categories of MDS by the International Prognostic Scoring System (IPSS) and the revised IPSS. Although the blast percentage in the BM of RA and cytopenia VR were both less than 5%, there was a significant difference in the level of WT1 between MDS and cytopenia VR. Conclusion: WT1 might be a good marker to differentiate low blast percentage MDS and cytopenia VR.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第897号 学位授与年月日:平成28年10月5日; Author: Maki Baba, Tomoko Hata, Hideki Tsushima, Sayaka Mori, Daisuke Sasaki, Kazuto Turuta, Hiroo Hasegawa, Koji Ando, Yasushi Sawayama, Daisuke Imanishi, Jun Taguchi, Katsunori Yanagihara, Masao Tomonaga, Shimeru Kamihira, Yasushi Miyazaki; Citation: Internal Meicine, 54(5), pp.445-451; 2015; Nagasaki University (長崎大学), 博士(医学) (2016-10-05)
• DOI: info:doi/10.2169/internalmedicine.54.3123; https://doi.org/info:doi/10.2169/internalmedicine.54.3123
• Persistent ID (NDL): info:ndljp/pid/10211586; https://dl.ndl.go.jp/pid/10211586
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-11-02T12:02:18+09:00
• Date Created (W3CDTF): 2020-12-21
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10069/36843; https://nagasaki-u.repo.nii.ac.jp/records/3666
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2021-03-07 再収集