Lung regeneration by fetal lung tissue implantation in a mouse pulmonary emphysema model 3-4

• Material Type: 博士論文
• ISSN: 1349-6867
• Title: Lung regeneration by fetal lung tissue implantation in a mouse pulmonary emphysema model
• Volume: 63 3-4
• Author/Editor: Uyama, Koh; Sakiyama, Shoji; Yoshida, Mitsuteru; Kenzaki, Koichiro; Toba, Hiroaki; Kawakami, Yukikiyo; Okumura, Kazumasa; Takizawa, Hiromitsu; Kondo, Kazuya; Tangoku, Akira
• Author Heading: Uyama, Koh; Sakiyama, Shoji; Yoshida, Mitsuteru; Kenzaki, Koichiro; Toba, Hiroaki; Kawakami, Yukikiyo; Okumura, Kazumasa; Takizawa, Hiromitsu; Kondo, Kazuya; Tangoku, Akira
• Publication, Distribution, etc.: Faculty of Medicine Tokushima University
• Publication Date: 2016-08
• Publication Date (W3CDTF): 2016-08
• Alternative Title: マウス肺気腫モデルにおける胎仔肺移植による肺再生; Fetal tissue for mouse lung regeneration
• Periodical title: The Journal of Medical Investigation
• Degree grantor/type: 徳島大学
• Date Granted: 2016-07-28
• Date Granted (W3CDTF): 2016-07-28
• Dissertation Number: 甲第2963号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第2963号
• Text Language Code: eng
• Subject Heading: Pallid mouse; COPD; lung regeneration; fetal tissue; pulmonary emphysema
• Target Audience: 一般
• Note (General): The mortality and morbidity of chronic obstructive pulmonary disease are high. However, no radical therapy has been developed to date. The purpose of this study was to evaluate whether fetal mouse lung tissue can grow and differentiate in the emphysematous lung. Fetal lung tissue from green fluorescent protein C57BL/6 mice at 16 days’ gestation was used as donor material. Twelve-month-old pallid mice were used as recipients. Donor lungs were cut into small pieces and implanted into the recipient left lung by performing thoracotomy under anesthesia. The recipient mice were sacrificed at day 7, 14, and 28 after implantation and used for histological examination. Well-developed spontaneous pulmonary emphysema was seen in 12-month-old pallid mice. Smooth and continuous connection between implanted fetal lung tissue and recipient lung was recognized. Air space expansion and donor tissue differentiation were observed over time. We could clearly distinguish the border zones between injected tissue and native tissue by the green fluorescence of grafts. Fetal mouse lung fragments survived and differentiated in the emphysematous lung of pallid mice. Implantation of fetal lung tissue in pallid mice might lead to further lung regeneration research from the perspective of respiratory and exercise function.
• DOI: info:doi/10.2152/jmi.63.182; https://doi.org/info:doi/10.2152/jmi.63.182
• Persistent ID (NDL): info:ndljp/pid/10211641; https://dl.ndl.go.jp/pid/10211641
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-11-02T12:02:18+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/111178
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2019-09-06 再収集