Dietary phosphate supplementation delays the onset of iron deficiency anemia and affects iron status in rats

• Material Type: 博士論文
• ISSN: 0271-5317
• Title: Dietary phosphate supplementation delays the onset of iron deficiency anemia and affects iron status in rats
• Volume: 35 11
• Author/Editor: Nakao, Mari; Yamamoto, Hironori; Nakahashi, Otoki; Ikeda, Shoko; Abe, Kotaro; Masuda, Masashi; Ishiguro, Mariko; Iwano, Masayuki; Takeda, Eiji; Taketani, Yutaka
• Author Heading: Nakao, Mari; Yamamoto, Hironori; Nakahashi, Otoki; Ikeda, Shoko; Abe, Kotaro; Masuda, Masashi; Ishiguro, Mariko; Iwano, Masayuki; Takeda, Eiji; Taketani, Yutaka
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2015-09-03
• Publication Date (W3CDTF): 2015-09-03
• Alternative Title: 食餌性リン負荷がラットにおける鉄欠乏性貧血の発症・進展と鉄代謝に及ぼす影響
• Periodical title: Nutrition Research
• Degree grantor/type: 徳島大学
• Date Granted: 2016-03-23
• Date Granted (W3CDTF): 2016-03-23
• Dissertation Number: 甲第2947号
• Degree Type: 博士（栄養学）
• Conferring No. (Dissertation): 甲第2947号
• Text Language Code: eng
• Subject Heading: Anemia; Dietary phosphate; Gene expression; iron-deficient; Rat
• Target Audience: 一般
• Note (General): Inorganic phosphate (Pi) plays critical roles in bone metabolism and is an essential component of 2,3-diphosphoglycerate (2,3-DPG). It has been reported that animals fed a low-iron diet modulate Pi metabolism, whereas the effect of dietary Pi on iron metabolism, particularly in iron deficiency anemia (IDA), is not fully understood. In this study, we hypothesized the presence of a link between Pi and iron metabolism and tested the hypothesis by investigating the effects of dietary Pi on iron status and IDA. Wistar rats aged 4 weeks were randomly assigned to 1 of 4 experimental dietary groups: normal iron content (Con Fe) + 0.5% Pi, low-iron (Low Fe) + 0.5% Pi, Con Fe + 1.5% Pi, and Low Fe + 1.5% Pi. Rats fed the 1.5% Pi diet for 14 days, but not for 28 days, maintained their anemia state and plasma erythropoietin concentrations within the reference range, even under conditions of low iron. In addition, plasma concentrations of 2,3-DPG were significantly increased by the 1.5% Pi diets and were positively correlated with plasma Pi concentration (r = 0.779; P < .001). Dietary Pi regulated the messenger RNA expression of iron-regulated genes, including divalent metal transporter 1, duodenal cytochrome B, and hepcidin. Furthermore, iron concentration in liver tissues was increased by the 1.5% Pi in Con Fe diet. These results suggest that dietary Pi supplementation delays the onset of IDA and increases plasma 2,3- DPG concentration, followed by modulation of the expression of iron-regulated genes.
• DOI: info:doi/10.1016/j.nutres.2015.09.001; https://doi.org/info:doi/10.1016/j.nutres.2015.09.001
• Persistent ID (NDL): info:ndljp/pid/10233209; https://dl.ndl.go.jp/pid/10233209
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• Date Accepted (W3CDTF): 2017-01-01T19:17:28+09:00
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• Periodical Title (URI): https://repo.lib.tokushima-u.ac.jp/109711
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