Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease

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Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease

Persistent ID (NDL): info:ndljp/pid/10233372

Material type: 博士論文

Author: Watanabe, Kenichi

Publisher: 新潟大学

Publication date: 2016-09-20

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: Objective : Coronary artery lesions (CALs)and a risk for early onset of atherosclerosis are major concerns following Kawasaki disease (KD).Intimal smo...

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Material Type: 博士論文
Title: Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease
Author/Editor: Watanabe, Kenichi
Publication, Distribution, etc.: 新潟大学
Publication Date: 2016-09-20
Publication Date (W3CDTF): 2016-09-20
Alternative Title: Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease
川崎病遠隔期における血管障害の新たなバイオマーカー：可溶型LR11
Degree grantor/type: 新潟大学
Date Granted: 2016-09-20
Date Granted (W3CDTF): 2016-09-20
Dissertation Number: 甲第4211号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第4211号
Text Language Code: eng
Subject Heading: LR11
smooth muscle cell
Kawasaki disease
biomarker
Note (General): Objective : Coronary artery lesions (CALs)and a risk for early onset of atherosclerosis are major concerns following Kawasaki disease (KD).Intimal smooth muscle cells (SMCs) have an important role in vascular lesions in KD.It is known that soluble LR11 (sLR11) is a novel biomarker for vascular lesions and LR11 is markedly expressed in intimal SMCs in atherosclerotic lesions. In this study, we hypothesized that sLR11 reflects the presence of vascular lesions late after KD. Methods : Twenty-three age-matched controls (group 1) and 59patients with a history of KD were enrolled : 36 with KD had normal coronary arteries or regressed aneurysms (group 2) and 23 had CALs (group 3). Results : Serum sLR11 levels in group 3 (median, interquartile range(IQR):11.1ng/mL,9.3-13.9ng/mL)were significantly higher than those in groups 1(8.4ng/mL,7.1-10.2ng/mL,p<0.001) and 2 (9.0ng/mL,7.7-10.1ng/mL,p<0.001).Levels of sLR11were positively correlated with levels of high sensitivity C-reactive protein (r = 0.480, p < 0.01) and lipoprotein(a) (r = 0.486, p < 0.01). Conclusion : These findings suggest that sLR11 reflects the development of vascular lesions in patients with serious CALs.
学位の種類: 博士（医学）. 報告番号: 甲第4211号. 学位記番号: 新大院博（医）甲第710号. 学位授与年月日: 平成28年9月20日
新大院博（医）甲第710号
Persistent ID (NDL): info:ndljp/pid/10233372
https://dl.ndl.go.jp/pid/10233372
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-01-01T19:17:28+09:00
Date Created (W3CDTF): 2019-08-05
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/45097
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp