Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-γ

The cover of this title could differ from library to library.

Available in National Diet Library

国立国会図書館デジタルコレクション

Digital data available（新潟大学）

Check on the publisher's website

Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-γ

Persistent ID (NDL): info:ndljp/pid/10233373

Material type: 博士論文

Author: Oyanagi, Takahito

Publisher: 新潟大学

Publication date: 2016-09-20

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 新潟大学,博士（医学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: Background: Excessive mucin secretion in the airway is an important feature of airway inflammatory diseases. . MUC5AC expression is regulated by a var...

Search by Bookstore

Read this material in an accessible format.

View materials in accessible formats for people with print disabilities (1Type)

Search by Bookstore

Read in Disability Resources

Other Services
- テキストデータ check it on 国立国会図書館デジタルコレクション

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-γ
Author/Editor: Oyanagi, Takahito
Publication, Distribution, etc.: 新潟大学
Publication Date: 2016-09-20
Publication Date (W3CDTF): 2016-09-20
Alternative Title: Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-γ
インターフェロンγによるヒト気道上皮細胞MUC5AC発現抑制
Degree grantor/type: 新潟大学
Date Granted: 2016-09-20
Date Granted (W3CDTF): 2016-09-20
Dissertation Number: 甲第4212号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第4212号
Text Language Code: eng
Subject Heading: MUC5AC
mucin
interferon-ɤ
bronchial epithelial cells
Sp1
Note (General): Background: Excessive mucin secretion in the airway is an important feature of airway inflammatory diseases. . MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such as cytokines.Little is known about the role of interferon (IFN)-γ in MUC5AC expression in human bronchial epithelial cells. Methods: Human pulmonary mucoepidermoid carcinoma cell line (NCI-H292) and normal human bronchial epithelial (NHBE) cells were used to assess the effects of IFN-γ on MUC5AC transcription. Results: Transforming growth factor (TGF)-α and double-stranded RNA (polyI:C)-induced MUC5AC mRNA and protein expression was repressed by IFN-γin a concentration-dependent manner. IFN-γ showed limited effects on TGF-α and polyI:C-induced activation of epidermal growth factor receptor (EGFR) and extracellular signale-regulated kinase(ERK). A chromatin immunoprecipitation assay indicated that Sp1 bound to its cognate sequence located on the MUC5AC promoter. The Sp1inhibitor mithramycin A inhibited MUC5AC mRNA expression, implying a critical role for Sp1 in MUC5AC induction. Importantly, IFN-γ impeded Sp1 binding to the MUC5AC promoter. Conclusions: These results suggest that IFN-γ represses MUC5AC expression, disturbing binding of Sp1 to its target sequences.
学位の種類: 博士（医学）. 報告番号: 甲第4212号. 学位記番号: 新大院博（医）甲第711号. 学位授与年月日: 平成28年9月20日
新大院博（医）甲第711号
Persistent ID (NDL): info:ndljp/pid/10233373
https://dl.ndl.go.jp/pid/10233373
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-01-01T19:17:28+09:00
Date Created (W3CDTF): 2019-08-05
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/45098
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp