Effect of Serum Leptin on Weight Gain Induced by Olanzapine in Female Patients with Schizophrenia

• Material Type: 博士論文
• Title: Effect of Serum Leptin on Weight Gain Induced by Olanzapine in Female Patients with Schizophrenia
• Author/Editor: Tsuneyama, Nobuto
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2016-09-20
• Publication Date (W3CDTF): 2016-09-20
• Alternative Title: Effect of Serum Leptin on Weight Gain Induced by Olanzapine in Female Patients with Schizophrenia; 女性統合失調症患者における、オランザピンによる体重増加への血中レプチンの影響
• Degree Grantor: 新潟大学
• Date Granted: 2016-09-20
• Date Granted (W3CDTF): 2016-09-20
• Dissertation Number: 甲第4215号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4215号
• Text Language Code: eng
• Note (General): Background :Olanzapine (OLZ) treatment is associated with a high risk of weight gain, and may cause abnormalities in glycolipid metabolism. Therefore, the underlying mechanism of OLZrelated weight gain is needed to clarify but not yet been adequately determined. In recent years, adipocytokines such as leptin, adiponectin, and tumor necrosis factor (TNF)-α, which play important roles in energy homeostasis, have been suggested as biomarkers of weight gain. Here, we determined if baseline plasma concentrations of leptin, adiponectin, and TNF-α predict weight gain following OLZ treatment.Methods : \ We recruited 31 schizophrenia outpatients (12 men and 19 women, 28.8 ± 10.2 years old) that were unmedicated or on another antipsychotic monotherapy medication. Baseline body mass index (BMI) and plasma levels of leptin, adiponectin, and TNF-α were obtained. All patients started or were switched to OLZ monotherapy for a maximum of 1 year. BMI was also obtained at the endpoint. Results : Mean BMI change following OLZ treatment was 2.1 ± 2.7 kg/m2. BMI change from baseline to endpoint negatively-correlated with baseline leptin levels in female patients (r = −0.514,P = 0.024), but not male patients. Baseline adiponectin or TNF-α levels were not correlated with BMI change. Conclusion : Baseline plasma leptin can have an effect on subsequent weight gain following OLZ treatment in female patients with schizophrenia.; 学位の種類: 博士（医学）. 報告番号: 甲第4215号. 学位記番号: 新大院博（医）甲第714号. 学位授与年月日: 平成28年9月20日; PLoS ONE 11(3): e0149518.; 新大院博（医）甲第714号
• DOI: info:doi/10.1371/journal.pone.0149518; https://doi.org/info:doi/10.1371/journal.pone.0149518
• Persistent ID (NDL): info:ndljp/pid/10233375; https://dl.ndl.go.jp/pid/10233375
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-01-01T19:17:28+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/45101
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp