Pharmacokinetic and pharmacodynamic comparison of sildenafil-bosentan and sildenafil-ambrisentan combination therapies for pulmonary hypertension

• Material Type: 博士論文
• Title: Pharmacokinetic and pharmacodynamic comparison of sildenafil-bosentan and sildenafil-ambrisentan combination therapies for pulmonary hypertension
• Volume: 9 1
• Author/Editor: Hakamata, Akio
• Author Heading: Hakamata, Akio
• Publication, Distribution, etc.: John Wiley and Sons
• Publication Date: 2016-01-12
• Publication Date (W3CDTF): 2016-01-12
• Alternative Title: 肺動脈性肺高血圧症に対するシルデナフィル-ボセンタン併用療法とシルデナフィル-アンブリセンタン併用療法における薬物動態学的および薬力学的な比較
• Periodical title: Clinical and Translational Science
• Degree grantor/type: 浜松医科大学
• Date Granted: 2016-03-14
• Date Granted (W3CDTF): 2016-03-14
• Dissertation Number: 甲第720号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 13802甲第720号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; To elucidate whether the pharmacokinetics (PK) and pharmacodynamics (PD) of sildenafil are influenced differently when it is coadministered with bosentan (S+B) or with ambrisentan (S+A), we evaluated the PK and PD profiles of sildenafil before and after 4-5 weeks of S+A or S+B treatment in patients with pulmonary arterial hypertension. The area under the plasma concentration-time curve of sildenafil was significantly higher in S+A treatment than in S+B treatment (165.8 ng･h/mL vs. 396.8 ng･h/mL, P=0.018) and the oral clearance of sildenafil was significantly lower after S+A treatment than after S+B treatment (120.6 L/h/kg vs. 50.4 L/h/kg, P=0.018). In the PD study, incremental shuttle walking distance was superior during treatment with S+A than during treatment with S+B (S+B; 280 m vs. S+A; 340 m, P=0.042). There were no concerns about safety with either combination therapy regime.
• DOI: 10.1111/cts.12382; https://doi.org/10.1111/cts.12382
• Persistent ID (NDL): info:ndljp/pid/10300479; https://dl.ndl.go.jp/pid/10300479
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-02-09T20:08:30+09:00
• Date Created (W3CDTF): 2018-08-27
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/3142; https://hama-med.repo.nii.ac.jp/records/3000
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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